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初次全膝关节置换术与初次全髋关节置换术后的住院疼痛及阿片类药物消耗情况比较:7330例接受快速康复治疗患者的结果

In-Hospital Pain and Opioid Consumption After Primary Total Knee Arthroplasty Compared to Primary Total Hip Arthroplasty: Results from 7330 Patients Treated in a Fast-Track Setting.

作者信息

Hofstad Janne Kristin, Wik Tina Strømdal, Klepstad Pål, Gjeilo Kari Hanne, Winther Siri Bjørgen, Foss Olav A

机构信息

Department of Orthopaedic Surgery, St. Olavs Hospital, Trondheim, Norway.

Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU Trondheim, Postbox 8905, 7491, Trondheim, Norway.

出版信息

Pain Ther. 2025 Jun;14(3):971-983. doi: 10.1007/s40122-025-00716-8. Epub 2025 Mar 14.

Abstract

INTRODUCTION

Differences in in-hospital pain and consumption of opioids after primary total hip arthroplasty (THA) and knee arthroplasty (TKA) have been rarely studied in a setting where the patient course is otherwise similar. The aim of this study was to compare early pain intensity and opioid usage between patients who have undergone THA and TKA to identify potential implications for outpatient surgery.

METHODS

This institutional register study included 4655 patients receiving THA and 2675 patients receiving TKA. Pain at rest and during mobilization were collected once preoperatively, and postoperatively at five time-points, twice on the Day of surgery, once each on day 1 and day 2 after surgery, and at discharge, on a numeric rating scale (NRS) 0-10. Rescue opioids in oral morphine-equivalent doses (MME) were consecutively registered. Postoperative mobilization was registered twice daily.

RESULTS

Overall mean pain were 2.0 (Cl 2.0-2.0) after THA and 2.3 (Cl 2.3-2.4) after TKA at rest, and 3.3 (Cl 3.3-3.3) and 3.7 (Cl 3.7-3.8) during mobilization, respectively. Patients undergoing TKA had a transient increase in pain intensity the day after surgery, whereas patients undergoing THA had improved pain levels. Outpatient criteria for pain (NRS < 5 during mobilization) were feasible for 37% of THA and 35% of TKA. Total median MME was 30.0 (0-573) after THA and 52.5 (0-390) after TKA. Patients undergoing TKA were less mobilized during hospitalization.

CONCLUSION

A comparable number of THA and TKA cases were eligible for same-day discharge based on outpatient discharge criteria for pain. Patients receiving TKA can expect an increase in pain intensity and opioid needs on the day after surgery.

摘要

引言

在患者病程其他方面相似的情况下,很少有人研究初次全髋关节置换术(THA)和膝关节置换术(TKA)后住院期间的疼痛及阿片类药物使用差异。本研究的目的是比较接受THA和TKA的患者的早期疼痛强度和阿片类药物使用情况,以确定对门诊手术的潜在影响。

方法

这项机构登记研究纳入了4655例接受THA的患者和2675例接受TKA的患者。术前、术后五个时间点收集静息和活动时的疼痛情况,手术当天两次,术后第1天和第2天各一次,出院时一次,采用0-10数字评分量表(NRS)。连续记录口服吗啡当量剂量(MME)的解救性阿片类药物。术后活动情况每天记录两次。

结果

THA术后静息时总体平均疼痛为2.0(可信区间2.0-2.0),TKA术后为2.3(可信区间2.3-2.4);活动时分别为3.3(可信区间3.3-3.3)和3.7(可信区间3.7-3.8)。接受TKA的患者术后第一天疼痛强度短暂增加,而接受THA的患者疼痛水平有所改善。疼痛门诊标准(活动时NRS<5)对37%的THA患者和35%的TKA患者可行。THA术后MME总中位数为30.0(0-573),TKA术后为52.5(0-390)。接受TKA的患者住院期间活动较少。

结论

根据疼痛门诊出院标准,相当数量的THA和TKA病例符合当日出院条件。接受TKA的患者术后第一天疼痛强度和阿片类药物需求可能会增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6e9/12085441/79265645250c/40122_2025_716_Fig1_HTML.jpg

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