Huang Zhongwei, Yong Eu-Leong
Department of Obstetrics and Gynaecology, National University of Singapore, Singapore.
Department of Obstetrics and Gynaecology, National University of Singapore, Singapore.
Best Pract Res Clin Obstet Gynaecol. 2016 Nov;37:46-55. doi: 10.1016/j.bpobgyn.2016.04.001. Epub 2016 May 18.
Ethnicity has not been accounted for in the diagnostic criteria for polycystic ovarian syndrome (PCOS). It is increasingly recognised that ethnic differences are likely contributors to the differing manifestations of PCOS. Generally, rates of PCOS may be lower in East Asians. It is clear that East Asians are less hirsute than Caucasians. Hirsutism cut-off thresholds need to be lower in East Asian populations than in Caucasian populations. Despite population-adjusted scoring, Caucasians have higher hirsutism rates among patients diagnosed with PCOS. Rates of hyperandrogenaemia do not appear to differ among PCOS subjects, although serum androstenedione appeared to be higher in Caucasians in one study. Interestingly, higher prevalence of the polycystic ovarian morphology has been reported in East Asian PCOS populations than in Caucasian PCOS subjects. Hence, there is a need for comparative studies across different ethnicities to establish whether epidemiological differences observed reflect a true ethnic difference in the phenotype of PCOS and whether there is an Asian phenotype for PCOS.
多囊卵巢综合征（PCOS）的诊断标准中未考虑种族因素。人们越来越认识到种族差异可能是PCOS不同表现的原因之一。一般来说，东亚地区PCOS的发病率可能较低。显然，东亚人比白种人毛发较少。东亚人群中多毛症的临界阈值需要低于白种人群体。尽管进行了人群校正评分，但在诊断为PCOS的患者中，白种人的多毛症发病率更高。在PCOS患者中，高雄激素血症的发生率似乎没有差异，尽管在一项研究中，白种人的血清雄烯二酮似乎更高。有趣的是，据报道，东亚PCOS人群中多囊卵巢形态的患病率高于白种PCOS患者。因此，需要开展不同种族间的比较研究，以确定观察到的流行病学差异是否反映了PCOS表型中真正的种族差异，以及是否存在PCOS的亚洲表型。
