Hong J S, Kwon H H, Park S Y, Jung J Y, Yoon J Y, Min S, Choi Y M, Suh D H
Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea; Acne and Rosacea Research Laboratory, Seoul National University Hospital, Seoul, Korea.
J Eur Acad Dermatol Venereol. 2015 Jan;29(1):42-7. doi: 10.1111/jdv.12432. Epub 2014 Mar 14.
Polycystic ovary syndrome (PCOS) is a common endocrinological disorder in women of childbearing-age. Although PCOS has common dermatological manifestations, including hirsutism, acne and androgenetic alopecia, little is known about the dermatological characteristics of PCOS patients in Asia.
The goal of this study is to elucidate the dermatological characteristics and metabolic and hormonal parameters of Korean PCOS patients classified by the three ASRM/ESHERE criteria.
We investigated 40 untreated PCOS patients who were newly diagnosed in the Department of Obstetrics & Gynecology of Seoul National University Hospital. Patients were classified according to the presence of irregular menstruation (IM), polycystic ovary morphology (PCOM) and hyperandrogenism (HA). Acne specific questionnaire, physical examination, and blood sampling were thoroughly conducted.
Twenty four patients (60.0%) met the criteria for the IM/HA/PCOM group and sixteen (40.0%) belonged to the IM/PCOM group. Acne was the most commonly observed dermatological manifestation (95.0%) followed by hirsutism (60.0%), seoborrhea (47.5%), acanthosis nigricans (20.0%) and androgenetic alopecia (12.5%). Hirsutism was more frequently observed in the IM/HA/PCOM group; the prevalence of other cutaneous manifestations did not differ significantly. Acne was most often observed on the face and most acne lesions were distributed on the forehead and cheek. Serum dehydroepiandrosterone sulphate level was higher in IM/HA/PCOM group, while serum cholesterol and high density lipoprotein concentrations were higher in the IM/PCOM group.
We described several dermatological manifestations and serum hormonal and metabolic parameters in Korean PCOS patients. Cutaneous manifestations might be the first signs of PCOS; therefore, dermatologists should be more aware of cutaneous manifestations of various ethnicities.
多囊卵巢综合征（PCOS）是育龄期女性常见的内分泌紊乱疾病。尽管PCOS有常见的皮肤表现，包括多毛、痤疮和雄激素性脱发，但关于亚洲PCOS患者的皮肤特征知之甚少。
本研究的目的是阐明根据美国生殖医学学会（ASRM）/欧洲人类生殖与胚胎学会（ESHERE）三项标准分类的韩国PCOS患者的皮肤特征、代谢和激素参数。
我们调查了40例在首尔国立大学医院妇产科新诊断的未经治疗的PCOS患者。根据月经不规律（IM）、多囊卵巢形态（PCOM）和高雄激素血症（HA）的存在对患者进行分类。全面进行痤疮特异性问卷调查、体格检查和血液采样。
24例患者（60.0%）符合IM/HA/PCOM组标准，16例（40.0%）属于IM/PCOM组。痤疮是最常见的皮肤表现（95.0%），其次是多毛（60.0%）、脂溢性皮炎（47.5%）、黑棘皮病（20.0%）和雄激素性脱发（12.5%）。多毛在IM/HA/PCOM组中更常见；其他皮肤表现的患病率无显著差异。痤疮最常出现在面部，大多数痤疮皮损分布在前额和脸颊。IM/HA/PCOM组血清硫酸脱氢表雄酮水平较高，而IM/PCOM组血清胆固醇和高密度脂蛋白浓度较高。
我们描述了韩国PCOS患者的几种皮肤表现以及血清激素和代谢参数。皮肤表现可能是PCOS的首发症状；因此，皮肤科医生应更加关注不同种族的皮肤表现。
