Cicek Ari Vuslat, Ilarslan Yagmur Deniz, Erman Baran, Sarkarati Bahram, Tezcan Ilhan, Karabulut Erdem, Oz Serife Gul, Tanriover Mine Durusu, Sengun Dilek, Berker Ezel
Department of Periodontology, Faculty of Dentistry, Hacettepe University, 3rd Floor, Sihhiye, 06100, Ankara, Turkey.
Pediatric Immunology Division, Ihsan Doğramacı Children's Hospital, Hacettepe University, Ankara, Turkey.
Inflammation. 2016 Aug;39(4):1547-57. doi: 10.1007/s10753-016-0390-7.
Statins possess a wide variety of pleiotropic properties that are independent of their lipid-lowering abilities such as attenuating inflammation, oxidative stress, coagulation, platelet aggregation and stimulating bone formation. The aim of the study is to evaluate the effect of statins on clinical periodontal parameters and gingival crevicular fluid (GCF) levels of IL-1β, IL-10, and myeloperoxidase (MPO) in inflammatory periodontal diseases. Seventy-nine subjects with hyperlipidemia and 48 systemically healthy controls (C) were included. Hyperlipidemic patients were either given a diet (HD) or prescribed statin (HS). Patients were classified into three subgroups as those who were periodontally healthy (h), who had gingivitis (g), or who had chronic periodontitis (p). Blood samples were collected for the measurement of lipid profiles. Plaque index (PI), gingival index (GI), probing pocket depth (PD), clinical attachment level (CAL), and percentage of bleeding on probing (BOP) were recorded. Gingival crevicular fluid levels of IL-1β, IL-10, and MPO were measured in order to determine the anti-inflammatory and antioxidant effects of statins. Probing depth values of the HSp group were significantly lower than those of the Cp group. Percentage of BOP of the HSg group was significantly lower than those of the HDg and Cg groups. While the IL-1β level of the HSp group was significantly lower than that of the HDp group, IL-10 levels of the HSg group were significantly higher than those of the HDg group. MPO levels were significantly lower in the HSg group when compared to those in the HDg and Cg groups. Statin use decreased the IL-1β and MPO levels and enhanced IL-10 in GCF. It can be suggested that statins may attenuate periodontal inflammation and progression of periodontal inflammation.
他汀类药物具有多种多效性特性，这些特性独立于其降脂能力，如减轻炎症、氧化应激、凝血、血小板聚集以及刺激骨形成。本研究的目的是评估他汀类药物对炎症性牙周疾病患者临床牙周参数以及龈沟液（GCF）中白细胞介素-1β（IL-1β）、白细胞介素-10（IL-10）和髓过氧化物酶（MPO）水平的影响。研究纳入了79名高脂血症患者和48名全身健康的对照者（C）。高脂血症患者要么接受饮食干预（HD），要么服用他汀类药物（HS）。患者被分为三个亚组：牙周健康者（h）、患牙龈炎者（g）或患慢性牙周炎者（p）。采集血样以测量血脂谱。记录菌斑指数（PI）、牙龈指数（GI）、探诊深度（PD）、临床附着水平（CAL）和探诊出血百分比（BOP）。测量龈沟液中IL-1β、IL-10和MPO的水平，以确定他汀类药物的抗炎和抗氧化作用。HSp组的探诊深度值显著低于Cp组。HSg组的BOP百分比显著低于HDg组和Cg组。HSp组的IL-1β水平显著低于HDp组，而HSg组的IL-10水平显著高于HDg组。与HDg组和Cg组相比，HSg组的MPO水平显著降低。使用他汀类药物可降低龈沟液中IL-1β和MPO水平，并提高IL-10水平。可以认为，他汀类药物可能减轻牙周炎症以及牙周炎症的进展。
