Carmona-Ruiz Israel Obed, Saucedo-de la Llata Eric, Moraga-Sánchez María Rosa, Romeu-Sarró Alberto
Ginecol Obstet Mex. 2015 Dec;83(12):750-9.
To determine the prevalence of polycystic ovary syndrome (PCOS) according to the three major diagnostic criteria previously described in an unselected group of women from Spain and to identify the most common phenotypes of the disease.
An observational, transversal prevalence study was carried out between July 1 2014 and October 31 2014. All participants received a questionnaire and underwent a physical and trans-vaginal ultrasound examination. Blood samples were also collected for analysis of metabolic markers and hormones. PCOS was diagnosed according to three major criteria: NIH, Rotterdam and AE-PCOS criteria. Following diagnosis women with PCOS were assigned to one of four phenotypes.
A total of 242 women were involved in the study. The prevalence for each major criteria was as follows: National Institute of Health (NIH) criteria had a prevalence of 1 4.88%, Rotterdam criteria had a prevalence of 29.34% and Androgen Excess and PCOS Society criteria presented a prevalence of 17.36%. The prevalence for each phenotype was: A, 40.85%; B, 25.35%; C, 8.45%; and D, 25.35%. PCOS women had more prevalence of hirsutism (36.61 %), infertility (25.35%), obesity (21.1 2%) and metabolic syndrome (11 .26%) than controls (7.01%, 6.43%, 5.84% and 2.33% respectively).
There is a rise in the prevalence of PCOS in Caucasian population with the classic phenotype (oligo-anovulation, hyperandrogenism, polycystic ovaries) being the most common presentation of the syndrome.
根据先前描述的三项主要诊断标准,确定西班牙一组未经挑选的女性中多囊卵巢综合征(PCOS)的患病率,并确定该疾病最常见的表型。
于2014年7月1日至2014年10月31日进行了一项观察性横断面患病率研究。所有参与者均接受问卷调查,并进行体格检查和经阴道超声检查。还采集血样以分析代谢标志物和激素。PCOS根据三项主要标准进行诊断:美国国立卫生研究院(NIH)标准、鹿特丹标准和雄激素过多与PCOS协会(AE-PCOS)标准。诊断后,患有PCOS的女性被分为四种表型之一。
共有242名女性参与了该研究。各主要标准的患病率如下:美国国立卫生研究院(NIH)标准的患病率为14.88%,鹿特丹标准的患病率为29.34%,雄激素过多与PCOS协会标准的患病率为17.36%。各表型的患病率为:A,40.85%;B,25.35%;C,8.45%;D,25.35%。与对照组(分别为7.01%、6.43%、5.84%和2.33%)相比,PCOS女性多毛症(36.61%)、不孕(25.35%)、肥胖(21.12%)和代谢综合征(11.26%)的患病率更高。
白种人群中PCOS的患病率有所上升,经典表型(排卵稀少、高雄激素血症、多囊卵巢)是该综合征最常见的表现形式。