高剂量的因可保妥适用于治疗中风后痉挛：它们安全且有效吗？ - Suppr

High doses of incobotulinumtoxinA for the treatment of post-stroke spasticity: are they safe and effective?

作者信息

Santamato Andrea, Ranieri Maurizio, Solfrizzi Vincenzo, Lozupone Madia, Vecchio Michele, Daniele Antonio, Greco Antonio, Seripa Davide, Logroscino Giancarlo, Panza Francesco

机构信息

a Physical Medicine and Rehabilitation Section-'OORR Hospital' , University of Foggia , Foggia , Italy.

b Geriatric Medicine-Memory Unit and Rare Disease Centre , University of Bari Aldo Moro , Bari , Italy.

出版信息

Expert Opin Drug Metab Toxicol. 2016 Aug;12(8):843-6. doi: 10.1080/17425255.2016.1198318. Epub 2016 Jun 17.

DOI:10.1080/17425255.2016.1198318

PMID:27291256

Abstract

摘要

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High doses of incobotulinumtoxinA for the treatment of post-stroke spasticity: are they safe and effective?高剂量的因可保妥适用于治疗中风后痉挛：它们安全且有效吗？

Expert Opin Drug Metab Toxicol. 2016 Aug;12(8):843-6. doi: 10.1080/17425255.2016.1198318. Epub 2016 Jun 17.

Long-term safety of repeated high doses of incobotulinumtoxinA injections for the treatment of upper and lower limb spasticity after stroke.重复高剂量注射英妥昔单抗A治疗中风后上肢和下肢痉挛的长期安全性。

J Neurol Sci. 2017 Jul 15;378:182-186. doi: 10.1016/j.jns.2017.04.052. Epub 2017 May 1.

[Using botulinum toxin (Botox) for treatment of patients with postroke spasticity].[使用肉毒杆菌毒素（保妥适）治疗中风后痉挛患者]

Zh Nevrol Psikhiatr Im S S Korsakova. 2009;109(6):87-90.

[The use of different doses of botulotoxin A in the treatment of early arm poststroke spasticity].[不同剂量A型肉毒毒素治疗脑卒中后早期上肢痉挛的应用]

Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(10):68-71.

Benefits and Risks of Non-Approved Injection Regimens for Botulinum Toxins in Spasticity.肉毒毒素治疗痉挛的未批准注射方案的获益与风险。

Drugs. 2017 Sep;77(13):1413-1422. doi: 10.1007/s40265-017-0786-1.

High doses of onabotulinumtoxinA in post-stroke spasticity: a retrospective analysis.大剂量A型肉毒杆菌毒素治疗中风后痉挛：一项回顾性分析。

J Neural Transm (Vienna). 2015 Sep;122(9):1283-7. doi: 10.1007/s00702-015-1384-6. Epub 2015 Feb 28.

Efficacy and safety of treatment with incobotulinum toxin A (botulinum neurotoxin type A free from complexing proteins; NT 201) in post-stroke upper limb spasticity.经治疗卒中后上肢痉挛的新型无复合蛋白的丁胺卡那毒素 A（A型肉毒毒素 NT 201）的疗效和安全性。

J Rehabil Med. 2011 May;43(6):486-92. doi: 10.2340/16501977-0796.

Efficacy and safety of incobotulinumtoxinA in post-stroke upper-limb spasticity in Japanese subjects: results from a randomized, double-blind, placebo-controlled study (J-PURE).一项随机、双盲、安慰剂对照研究（J-PURE）：在日本受试者中，应用依库珠单抗毒素 A 治疗脑卒中后上肢痉挛的疗效和安全性。

J Neurol. 2020 Jul;267(7):2029-2041. doi: 10.1007/s00415-020-09777-5. Epub 2020 Mar 26.

Can botulinum toxin type A injection technique influence the clinical outcome of patients with post-stroke upper limb spasticity? A randomized controlled trial comparing manual needle placement and ultrasound-guided injection techniques.A型肉毒毒素注射技术会影响中风后上肢痉挛患者的临床疗效吗？一项比较手工进针法与超声引导注射技术的随机对照试验。

J Neurol Sci. 2014 Dec 15;347(1-2):39-43. doi: 10.1016/j.jns.2014.09.016. Epub 2014 Sep 19.

Intramuscular injection of botulinum toxin for the treatment of wrist and finger spasticity after a stroke.肌肉注射肉毒杆菌毒素治疗中风后手腕和手指痉挛。

N Engl J Med. 2002 Aug 8;347(6):395-400. doi: 10.1056/NEJMoa011892.

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Intramuscular Botulinum Neurotoxin Serotypes E and A Elicit Distinct Effects on SNAP25 Protein Fragments, Muscular Histology, Spread and Neuronal Transport: An Integrated Histology-Based Study in the Rat.肌肉内注射肉毒神经毒素 E 型和 A 型对 SNAP25 蛋白片段、肌肉组织学、扩散和神经元转运有不同的影响：大鼠基于组织学的综合研究。

Toxins (Basel). 2024 May 12;16(5):225. doi: 10.3390/toxins16050225.

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Toxins (Basel). 2024 Apr 9;16(4):184. doi: 10.3390/toxins16040184.

Botulinum Toxin-A High-Dosage Effect on Functional Outcome and Spasticity-Related Pain in Subjects with Stroke.肉毒毒素 A 高剂量对脑卒中患者功能结局和痉挛相关疼痛的影响。

Toxins (Basel). 2023 Aug 18;15(8):509. doi: 10.3390/toxins15080509.

Reasons and Determinants of BoNT-A Treatment Discontinuation in Patients Living with Spasticity: A 10-Year Retrospective Analysis.肉毒毒素 A 治疗痉挛患者停药的原因和决定因素：一项 10 年回顾性分析。

Toxins (Basel). 2022 Sep 29;14(10):675. doi: 10.3390/toxins14100675.

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Toxins (Basel). 2021 Aug 22;13(8):584. doi: 10.3390/toxins13080584.

Ergonomic Recommendations in Ultrasound-Guided Botulinum Neurotoxin Chemodenervation for Spasticity: An International Expert Group Opinion.超声引导肉毒毒素化学神经切断术治疗痉挛的人体工效学建议：国际专家小组意见。

Toxins (Basel). 2021 Mar 31;13(4):249. doi: 10.3390/toxins13040249.

An Integrated Pharmacophore/Docking/3D-QSAR Approach to Screening a Large Library of Products in Search of Future Botulinum Neurotoxin A Inhibitors.一种整合的药效团/对接/3D-QSAR 方法，用于筛选大型产品库以寻找未来的肉毒神经毒素 A 抑制剂。

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High Dosage of Botulinum Toxin Type A in Adult Subjects with Spasticity Following Acquired Central Nervous System Damage: Where Are We at?A型肉毒毒素高剂量治疗获得性中枢神经系统损伤后痉挛状态的成人患者：我们现在处于什么位置？

Toxins (Basel). 2020 May 10;12(5):315. doi: 10.3390/toxins12050315.

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High doses of incobotulinumtoxinA for the treatment of post-stroke spasticity: are they safe and effective?

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