Masoro E J, Iwasaki K, Gleiser C A, McMahan C A, Seo E J, Yu B P
Department of Physiology, University of Texas Health Science Center, San Antonio 78284-7756.
Am J Clin Nutr. 1989 Jun;49(6):1217-27. doi: 10.1093/ajcn/49.6.1217.
Chronic nephropathy involving glomerular sclerosis markedly progresses in severity with age in male Fischer 344 rats fed ad libitum. Restricting food intake by 40% almost totally prevents progression of these lesions. Restricting food intake by 40% without restricting protein intake is also highly effective although somewhat less so than food restriction that includes protein restriction. These findings indicate that reducing the intake of protein is not the major reason for the retardation by food restriction of the age-associated progression of nephropathy in rats.
在随意进食的雄性Fischer 344大鼠中，涉及肾小球硬化的慢性肾病严重程度会随着年龄显著进展。将食物摄入量限制40%几乎完全可以防止这些病变的进展。在不限制蛋白质摄入量的情况下将食物摄入量限制40%也非常有效，尽管其效果略逊于包括蛋白质限制在内的食物限制。这些发现表明，减少蛋白质摄入量并非食物限制延缓大鼠年龄相关肾病进展的主要原因。
