间歇性禁食与持续热量限制：哪一种更有利于减肥？

Intermittent Fasting versus Continuous Calorie Restriction: Which Is Better for Weight Loss?

机构信息

Special Medicine Department, Medical College, Qingdao University, Qingdao 266071, China.

Clinical Medicine Department, Medical College, Qingdao University, Qingdao 266071, China.

出版信息

Nutrients. 2022 Apr 24;14(9):1781. doi: 10.3390/nu14091781.

We conducted a systematic review and meta-analysis of randomized clinical trials and pilot trial studies to compare the effectiveness of intermittent fasting (IF) and continuous calorie restriction (CCR) in overweight and obese people. The parameters included body mass index (BMI), body weight, and other metabolism-related indicators. A systematic search in PubMed, Embase, Cochrane Library, and Web of Science was conducted up to January 2022. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were used to measure the effectiveness. Publication bias was assessed using Egger's test. The stability of the results was evaluated using sensitivity analyses. The significance of body weight change (SMD = -0.21, 95% CI (-0.40, -0.02) = 0.028) was more significant after IF than CCR. There was no significant difference in BMI (SMD = 0.02, 95% CI (-0.16, 0.20) = 0.848) between IF and CCR. These findings suggest that IF may be superior to CCR for weight loss in some respects.

我们进行了一项系统评价和荟萃分析，纳入了随机临床试验和初步试验研究，旨在比较间歇性禁食（IF）和持续热量限制（CCR）在超重和肥胖人群中的有效性。参数包括体重指数（BMI）、体重和其他代谢相关指标。系统检索了 PubMed、Embase、Cochrane 图书馆和 Web of Science，检索时间截至 2022 年 1 月。使用标准化均数差（SMD）和 95%置信区间（CI）来衡量有效性。采用 Egger 检验评估发表偏倚。通过敏感性分析评估结果的稳定性。体重变化的显著性（SMD = -0.21，95%CI（-0.40，-0.02）= 0.028）在 IF 组比 CCR 组更显著。IF 和 CCR 组之间 BMI 的差异无统计学意义（SMD = 0.02，95%CI（-0.16，0.20）= 0.848）。这些发现表明，IF 在某些方面可能优于 CCR 来减轻体重。