2-Trifluoromethylthiolation of glycals.
作者信息
Yu Yang, Xiong De-Cai, Ye Xin-Shan
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road No. 38, Beijing 100191, China.
出版信息
Org Biomol Chem. 2016 Jul 6;14(27):6403-6. doi: 10.1039/c6ob01001f.
PMID:27291685
Abstract
Methods for trifluoromethylthiolation are very limited. To tackle this problem, a mild and efficient approach to the 2-trifluoromethylthiolation of glycals has been developed. This protocol employed N-trifluoromethylthiosaccharin as the trifluoromethylthiolating reagent, TMSCl as the activator, and DBU as the base, affording 2-trifluoromethylthioglycals in good yields. These trifluoromethylthiolated carbohydrates may benefit the development of carbohydrate-based drugs.
摘要
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