长链非编码RNA MALAT1通过靶向miR-204在肺腺癌中发挥致癌作用。
LncRNA MALAT1 exerts oncogenic functions in lung adenocarcinoma by targeting miR-204.
作者信息
Li Jipeng, Wang Jianhua, Chen Yin, Li Shanfeng, Jin Mingwei, Wang Huaying, Chen Zhe, Yu Wanjun
机构信息
Department of Central Laboratory, Yinzhou People's Hospital Ningbo 315040, China.
Department of Respiratory and Critical Care Medicine, Yinzhou People's Hospital Ningbo 315040, China.
出版信息
Am J Cancer Res. 2016 May 1;6(5):1099-107. eCollection 2016.
Abstract
Accumulating evidence indicates that the lncRNAs play a critical role in cancer progression and metastasis. In this study, we found that MALAT1 upregulation was associated with larger tumor size and lymph-node metastasis, and also correlated with shorter overall survival of lung adenocarcinoma patients. Furthermore, MALAT1 promotes EMT and metastasis of lung adenocarcinoma cells in vitro and in vivo. In particular, MALAT1 upregulated the expression of miR-204 target gene SLUG through competitively 'spongeing' miR-204. In summary we unveil a branch of the MALAT1/miR-204/SLUG pathway that regulates the progression of lung adenocarcinoma.
摘要
越来越多的证据表明，长链非编码RNA（lncRNAs）在癌症进展和转移中起关键作用。在本研究中，我们发现MALAT1的上调与更大的肿瘤大小和淋巴结转移相关，并且还与肺腺癌患者较短的总生存期相关。此外，MALAT1在体外和体内均促进肺腺癌细胞的上皮-间质转化（EMT）和转移。特别地，MALAT1通过竞争性“吸附”miR-204上调了miR-204靶基因SLUG的表达。总之，我们揭示了一条调控肺腺癌进展的MALAT1/miR-204/SLUG信号通路分支。
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