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本文引用的文献

1
Endogenous Nodal promotes melanoma undergoing epithelial-mesenchymal transition via Snail and Slug in vitro and in vivo.内源性 Nodal 通过 Snail 和 Slug 在体外和体内促进黑色素瘤发生上皮-间充质转化。
Am J Cancer Res. 2015 May 15;5(6):2098-112. eCollection 2015.
2
Auto-regulation of Slug mediates its activity during epithelial to mesenchymal transition.蛞蝓蛋白（Slug）的自动调节介导其在上皮-间质转化过程中的活性。
Biochim Biophys Acta. 2015 Sep;1849(9):1209-18. doi: 10.1016/j.bbagrm.2015.07.006. Epub 2015 Jul 11.
3
The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer.长链非编码RNA H19通过作为微小RNA海绵在结直肠癌中促进上皮-间质转化。
Oncotarget. 2015 Sep 8;6(26):22513-25. doi: 10.18632/oncotarget.4154.
4
MiR-204, down-regulated in retinoblastoma, regulates proliferation and invasion of human retinoblastoma cells by targeting CyclinD2 and MMP-9.微小RNA-204在视网膜母细胞瘤中表达下调，通过靶向细胞周期蛋白D2和基质金属蛋白酶-9调控人视网膜母细胞瘤细胞的增殖和侵袭。
FEBS Lett. 2015 Feb 27;589(5):645-50. doi: 10.1016/j.febslet.2015.01.030. Epub 2015 Jan 31.
5
Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205.长链非编码 RNA MALAT1 通过 Ezh2 促进肾透明细胞癌的侵袭转移并与 miR-205 相互作用。
Cancer Res. 2015 Apr 1;75(7):1322-31. doi: 10.1158/0008-5472.CAN-14-2931. Epub 2015 Jan 19.
6
Upregulation of long non-coding RNA MALAT1 correlates with tumor progression and poor prognosis in clear cell renal cell carcinoma.长链非编码RNA MALAT1的上调与透明细胞肾细胞癌的肿瘤进展及不良预后相关。
Tumour Biol. 2015 Apr;36(4):2947-55. doi: 10.1007/s13277-014-2925-6. Epub 2014 Dec 6.
7
MiR-204 inhibits human NSCLC metastasis through suppression of NUAK1.微小RNA-204通过抑制NUAK1来抑制人非小细胞肺癌转移。
Br J Cancer. 2014 Dec 9;111(12):2316-27. doi: 10.1038/bjc.2014.580. Epub 2014 Nov 20.
8
A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma.TGF-β 激活的长非编码 RNA 促进肝癌侵袭转移级联反应。
Cancer Cell. 2014 May 12;25(5):666-81. doi: 10.1016/j.ccr.2014.03.010. Epub 2014 Apr 24.
9
Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long non-coding RNA MALAT1.hsa-miR-125b 通过下调癌基因 SIRT7 和致癌长非编码 RNA MALAT1 抑制膀胱癌的发展。
FEBS Lett. 2013 Nov 29;587(23):3875-82.
10
miR-204 inhibits epithelial to mesenchymal transition by targeting slug in intrahepatic cholangiocarcinoma cells.微小RNA-204通过靶向肝内胆管癌细胞中的蛞蝓样蛋白抑制上皮-间质转化
Cell Physiol Biochem. 2013;32(5):1331-41. doi: 10.1159/000354531. Epub 2013 Nov 22.

长链非编码RNA MALAT1通过靶向miR-204在肺腺癌中发挥致癌作用。

LncRNA MALAT1 exerts oncogenic functions in lung adenocarcinoma by targeting miR-204.

作者信息

Li Jipeng, Wang Jianhua, Chen Yin, Li Shanfeng, Jin Mingwei, Wang Huaying, Chen Zhe, Yu Wanjun

机构信息

Department of Central Laboratory, Yinzhou People's Hospital Ningbo 315040, China.

Department of Respiratory and Critical Care Medicine, Yinzhou People's Hospital Ningbo 315040, China.

出版信息

Am J Cancer Res. 2016 May 1;6(5):1099-107. eCollection 2016.

PMID:27294002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4889723/
Abstract

Accumulating evidence indicates that the lncRNAs play a critical role in cancer progression and metastasis. In this study, we found that MALAT1 upregulation was associated with larger tumor size and lymph-node metastasis, and also correlated with shorter overall survival of lung adenocarcinoma patients. Furthermore, MALAT1 promotes EMT and metastasis of lung adenocarcinoma cells in vitro and in vivo. In particular, MALAT1 upregulated the expression of miR-204 target gene SLUG through competitively 'spongeing' miR-204. In summary we unveil a branch of the MALAT1/miR-204/SLUG pathway that regulates the progression of lung adenocarcinoma.

摘要

越来越多的证据表明，长链非编码RNA（lncRNAs）在癌症进展和转移中起关键作用。在本研究中，我们发现MALAT1的上调与更大的肿瘤大小和淋巴结转移相关，并且还与肺腺癌患者较短的总生存期相关。此外，MALAT1在体外和体内均促进肺腺癌细胞的上皮-间质转化（EMT）和转移。特别地，MALAT1通过竞争性“吸附”miR-204上调了miR-204靶基因SLUG的表达。总之，我们揭示了一条调控肺腺癌进展的MALAT1/miR-204/SLUG信号通路分支。