Chen Hui, Liu Lin, Xing Gang, Zhang Dan, A Niumuqie, Huang Jianlin, Li Yaling, Zhao Ge, Liu Minghua
School of Pharmacy, Southwest Medical University, Luzhou, China.
Department of Drug Dispensing, The Third Hospital of Mianyang, Sichuan Mental Health Center, MianYang, China.
Front Immunol. 2025 Feb 14;16:1517495. doi: 10.3389/fimmu.2025.1517495. eCollection 2025.
Lung cancer, characterized by its high morbidity and mortality rates, has the capability to metastasize to various organs, thereby amplifying its detrimental impact and fatality. The metastasis of lung cancer is a complex biological phenomenon involving numerous physiological transformations. Exosomes, small membranous vesicles enriched with biologically active components, are pivotal in mediating intercellular communication and regulating physiological functions due to their specificity and stability. Extensive research has elucidated the production and functions of exosomes in cancer contexts. Multitude of evidence demonstrates a strong association between lung cancer metastasis and exosomes. Additionally, the concept of the pre-metastatic niche is crucial in the metastatic process facilitated by exosomes. This review emphasizes the role of exosomes in mediating lung cancer metastasis and their impact on the disease's development and the progression to other tissues. Furthermore, it explores the potential of exosomes as biomarkers for lung cancer metastasis, offering significant insights for future clinical advancements.
肺癌具有高发病率和高死亡率的特点，能够转移至各个器官，从而加剧其有害影响和致死率。肺癌转移是一种复杂的生物学现象，涉及众多生理变化。外泌体是富含生物活性成分的小膜泡，因其特异性和稳定性，在介导细胞间通讯和调节生理功能方面起着关键作用。广泛的研究已经阐明了外泌体在癌症环境中的产生和功能。大量证据表明肺癌转移与外泌体之间存在密切关联。此外，前转移生态位的概念在由外泌体促进的转移过程中至关重要。本综述强调了外泌体在介导肺癌转移中的作用及其对疾病发展和向其他组织进展的影响。此外，还探讨了外泌体作为肺癌转移生物标志物的潜力，为未来的临床进展提供了重要见解。
