Department of Environmental and Global Health, University of Florida, Gainesville, FL, USA; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS, USA.
J Clin Virol. 2016 Aug;81:31-3. doi: 10.1016/j.jcv.2016.05.017. Epub 2016 May 31.
Influenza D virus (IDV), a novel influenza virus with proposed classification: family Orthomyxoviridae, genus Influenzavirus D, species Influenza D virus, has been associated with influenza-like illness in cattle and swine. More recently, anti-IDV antibodies have also been detected in small ruminants. A seroprevalence of approximately 1.3% has been estimated for the general human population.
To gain insights on the zoonotic potential of IDV to human adults with occupational exposure to cattle in north central Florida.
A cross-sectional serological study was performed on human serum samples from 35 cattle-exposed and 11 non-cattle-exposed adults to screen for IDV antibodies using hemagglutination inhibition (HI) and microneutralization (MN) assays.
A seroprevalence of 91% was detected via HI assay, and 97% by MN assay among individuals working with cattle in Florida. Among non-cattle-exposed individuals, seropositivity determined via MN assay (only) was lower (18%).
IDV poses a zoonotic risk to cattle-exposed workers, based on detection of high seroprevalence (94-97%). Whereas it is still unknown whether IDV causes disease in humans, our studies indicate that the virus may be an emerging pathogen among cattle-workers.
流感 D 病毒（IDV）是一种新型流感病毒，建议分类为：正粘病毒科、流感病毒属 D、流感病毒 D 种，与牛和猪的流感样疾病有关。最近，在小反刍动物中也检测到了抗 IDV 抗体。估计普通人群的血清阳性率约为 1.3%。
了解 IDV 对佛罗里达州中北部接触牛的成年人群的人畜共患潜力。
对 35 名接触牛的人和 11 名非接触牛的成年人的血清样本进行了横断面血清学研究，使用血凝抑制（HI）和微量中和（MN）试验来筛选 IDV 抗体。
在佛罗里达州接触牛的人群中，通过 HI 试验检测到的血清阳性率为 91%，通过 MN 试验检测到的血清阳性率为 97%。在非接触牛的人群中，通过 MN 试验（仅）检测到的血清阳性率较低（18%）。
根据高血清阳性率（94-97%），IDV 对接触牛的工人构成了人畜共患风险。虽然目前尚不清楚 IDV 是否会导致人类疾病，但我们的研究表明，该病毒可能是牛工人群中的一种新兴病原体。
