Hutchinson Edward C, Amorim Maria João, Yamauchi Yohei
MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
Católica Biomedical Research Centre (CBR), Católica Medical School, Universidade Católica Portuguesa, Lisbon, Portugal.
Methods Mol Biol. 2025;2890:1-26. doi: 10.1007/978-1-0716-4326-6_1.
Influenza, a serious illness of humans and domesticated animals, has been studied intensively for many years. It therefore provides an example of how much we can learn from detailed studies of an infectious disease, and of how even the most intensive scientific research leaves further questions to answer. This introduction is written for researchers who have become interested in one of these unanswered questions, but who may not have previously worked on influenza. To investigate these questions, researchers must not only have a firm grasp of relevant methods and protocols; they must also be familiar with the basic details of our current understanding of influenza. This chapter briefly covers the burden of disease that has driven influenza research, summarizes how our thinking about influenza has evolved over time, and sets out key features of influenza viruses by discussing how we classify them and what we currently understand of their replication. It does not aim to be comprehensive, as any researcher will read deeply into the specific areas that have grasped their interest. Instead, it aims to provide a general summary of how we came to think about influenza in the way we do now, in the hope that the reader's own research will help us to understand it better.
流感是一种影响人类和家畜的严重疾病，多年来一直受到深入研究。因此，它为我们展示了通过对一种传染病进行详细研究我们能够学到多少东西，也展示了即使是最深入的科学研究也仍有进一步的问题有待解答。本引言是为那些对这些未解决问题之一产生兴趣，但之前可能没有从事过流感研究的研究人员而写的。为了研究这些问题，研究人员不仅必须牢固掌握相关方法和规程；他们还必须熟悉我们目前对流感的基本认识细节。本章简要介绍了推动流感研究的疾病负担，总结了我们对流感的认识是如何随时间演变的，并通过讨论我们如何对流感病毒进行分类以及我们目前对其复制的理解，阐述了流感病毒的关键特征。它并不追求全面，因为任何研究人员都会深入研究引起他们兴趣的特定领域。相反，它旨在对我们现在思考流感的方式进行总体概述，希望读者自己的研究将有助于我们更好地理解流感
