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本文引用的文献

1
Susceptibility to echinocandins of Candida spp. strains isolated in Italy assessed by European Committee for Antimicrobial Susceptibility Testing and Clinical Laboratory Standards Institute broth microdilution methods.采用欧洲抗菌药物敏感性试验委员会和临床实验室标准协会肉汤微量稀释法评估意大利分离的念珠菌属菌株对棘白菌素类药物的敏感性。
BMC Microbiol. 2015 May 20;15:106. doi: 10.1186/s12866-015-0442-4.
2
Echinocandin resistance: an emerging clinical problem?棘白菌素耐药性：一个新出现的临床问题？
Curr Opin Infect Dis. 2014 Dec;27(6):484-92. doi: 10.1097/QCO.0000000000000111.
3
Echinocandin resistance, susceptibility testing and prophylaxis: implications for patient management.棘白菌素耐药性、药敏试验及预防：对患者管理的影响
Drugs. 2014 Sep;74(14):1573-85. doi: 10.1007/s40265-014-0286-5.
4
Emergence of echinocandin-resistant Candida spp. in a hospital setting: a consequence of 10 years of increasing use of antifungal therapy?在医院环境中出现棘白菌素类耐药念珠菌属：是 10 年抗真菌治疗增加使用的结果？
Eur J Clin Microbiol Infect Dis. 2014 Sep;33(9):1489-96. doi: 10.1007/s10096-014-2096-9. Epub 2014 Apr 9.
5
EUCAST technical note on Candida and micafungin, anidulafungin and fluconazole.欧洲临床微生物与感染性疾病学会（EUCAST）关于念珠菌与米卡芬净、阿尼芬净和氟康唑的技术说明。
Mycoses. 2014 Jun;57(6):377-9. doi: 10.1111/myc.12170. Epub 2014 Jan 13.
6
Multicenter study of anidulafungin and micafungin MIC distributions and epidemiological cutoff values for eight Candida species and the CLSI M27-A3 broth microdilution method.八株念珠菌及 CLSI M27-A3 肉汤微量稀释法的两性霉素 B 及米卡芬净 MIC 分布与流行病学折点的多中心研究
Antimicrob Agents Chemother. 2014;58(2):916-22. doi: 10.1128/AAC.02020-13. Epub 2013 Nov 25.
7
Comparison between the EUCAST procedure and the Etest for determination of the susceptibility of Candida species isolates to micafungin.EUCAST 程序与 Etest 测定分离的念珠菌属对米卡芬净敏感性的比较。
Antimicrob Agents Chemother. 2013 Nov;57(11):5767-70. doi: 10.1128/AAC.01032-13. Epub 2013 Aug 26.
8
Rapid emergence of echinocandin resistance during Candida kefyr fungemia treatment with caspofungin.卡泊芬净治疗克柔念珠菌血症时出现棘白菌素耐药的快速出现。
Antimicrob Agents Chemother. 2013 May;57(5):2380-2. doi: 10.1128/AAC.02037-12. Epub 2013 Feb 25.
9
ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients.ESCMID*指南：2012 年念珠菌病的诊断和管理：非中性粒细胞减少成年患者。
Clin Microbiol Infect. 2012 Dec;18 Suppl 7:19-37. doi: 10.1111/1469-0691.12039.
10
ESCMID* guideline for the diagnosis and management of Candida diseases 2012: diagnostic procedures.ESCMID* 指南：2012 年念珠菌病的诊断与管理：诊断程序。
Clin Microbiol Infect. 2012 Dec;18 Suppl 7:9-18. doi: 10.1111/1469-0691.12038.

Etest法与EUCAST法对念珠菌分离株进行米卡芬净抗真菌药敏试验的多中心比较

Multicenter Comparison of the Etest and EUCAST Methods for Antifungal Susceptibility Testing of Candida Isolates to Micafungin.

作者信息

Bougnoux M-E, Dannaoui E, Accoceberry I, Angoulvant A, Bailly E, Botterel F, Chevrier S, Chouaki T, Cornet M, Dalle F, Datry A, Dupuis A, Fekkar A, Gangneux J P, Guitard J, Hennequin C, Le Govic Y, Le Pape P, Maubon D, Ranque S, Sautour M, Sendid B, Chandenier J

机构信息

Université Paris-Descartes, Faculté de Médecine, and Unité de Parasitologie-Mycologie, Service de Microbiologie, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.

Université Paris-Descartes, Faculté de Médecine, and Unité de Parasitologie-Mycologie, Service de Microbiologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France

出版信息

Antimicrob Agents Chemother. 2016 Jul 22;60(8):5088-91. doi: 10.1128/AAC.00630-16. Print 2016 Aug.

DOI:10.1128/AAC.00630-16
PMID:27297480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4958160/
Abstract

In vitro susceptibility of 933 Candida isolates, from 16 French hospitals, to micafungin was determined using the Etest in each center. All isolates were then sent to a single center for determination of MICs by the EUCAST reference method. Overall essential agreement between the two tests was 98.5% at ±2 log2 dilutions and 90.2% at ±1 log2 dilutions. Categorical agreement was 98.2%. The Etest is a valuable alternative to EUCAST for the routine determination of micafungin MICs in medical mycology laboratories.

摘要

采用Etest法在16家法国医院对933株念珠菌分离株进行体外对米卡芬净的药敏试验，各中心均开展此项工作。随后，所有分离株均被送至单一中心，采用欧洲抗菌药物敏感性试验委员会（EUCAST）参考方法测定最低抑菌浓度（MIC）。两种检测方法在±2倍对数2稀释度时的总体基本一致性为98.5%，在±1倍对数2稀释度时为90.2%。分类一致性为98.2%。对于医学真菌学实验室常规测定米卡芬净的MIC，Etest是EUCAST的一种有价值的替代方法。