Block Andrea, Schipf Sabine, Van der Auwera Sandra, Hannemann Anke, Nauck Matthias, John Ulrich, Völzke Henry, Freyberger Harald Jürgen, Dörr Marcus, Felix Stephan, Zygmunt Marek, Wallaschofski Henri, Grabe Hans Jörgen
a Department of Psychiatry and Psychotherapy , University Medicine Greifswald , Germany ;
b Institute for Community Medicine , University Medicine Greifswald , Germany ;
Nord J Psychiatry. 2016 Nov;70(8):611-20. doi: 10.1080/08039488.2016.1191535. Epub 2016 Jun 14.
Major depressive disorder (MDD) has been associated with the Metabolic Syndrome (MetS). As previous data strongly suggested sex and age effects on this association, this study aimed to analyse the association between MDD and MetS in two general population samples under explicit consideration of sex and age.
This study analysed cross-sectional data based on two independent general population samples: SHIP-0 (n = 4083; 20-81 years; 49.4% male) and SHIP-TREND-0 (n = 3957; 20-83 years; 49.0% male) that were part of the Study of Health in Pomerania. MDD (SHIP-0: 12.6%; SHIP-TREND-0: 27.2%) was assessed using the Composite International Diagnostic-Screener (CID-S) in both samples. Interview assessment of MDD diagnosis according to Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) criteria was performed in SHIP-TREND-0 (18.1% MDD). MetS was defined by abdominal obesity, elevated blood pressure, elevated glucose, elevated triglycerides and reduced high-density lipoprotein cholesterol according to established criteria. Data analysis was performed sex- and age-stratified.
Prevalence of MetS was high in both samples: 19.4% of females and 30.2% of males in SHIP-0 and 22.1% and 33.2% in SHIP-TREND-0, respectively. Effect modifications were observed by sex and age on the association between MDD and MetS. Particularly, younger females (20-49 years) with MDD were more often affected by MetS than younger females without MDD: OR = 2.21 (95% CI = 1.39-3.50). This association vanished in elderly participants (50-82 years).
The data suggest that especially younger (presumably pre-menopausal) females with MDD are more likely to have MetS than those without major depressive disorders, and that age extenuates this association.
重度抑郁症（MDD）与代谢综合征（MetS）有关。由于先前的数据强烈表明性别和年龄对这种关联有影响，本研究旨在在明确考虑性别和年龄的情况下，分析两个普通人群样本中MDD与MetS之间的关联。
本研究基于两个独立的普通人群样本分析横断面数据：SHIP - 0（n = 4083；20 - 81岁；男性占49.4%）和SHIP - TREND - 0（n = 3957；20 - 83岁；男性占49.0%），它们是波美拉尼亚健康研究的一部分。在两个样本中均使用综合国际诊断筛查器（CID - S）评估MDD（SHIP - 0：12.6%；SHIP - TREND - 0：27.2%）。在SHIP - TREND - 0中根据《精神障碍诊断与统计手册》第四版（DSM - IV）标准对MDD诊断进行访谈评估（MDD占18.1%）。根据既定标准，MetS由腹部肥胖、血压升高、血糖升高、甘油三酯升高和高密度脂蛋白胆固醇降低来定义。数据分析按性别和年龄分层进行。
两个样本中MetS的患病率都很高：SHIP - 0中女性为19.4%，男性为30.2%；SHIP - TREND - 0中女性为22.1%，男性为33.2%。观察到性别和年龄对MDD与MetS之间的关联有效应修正。特别是，患有MDD的年轻女性（20 - 49岁）比未患MDD的年轻女性更常受到MetS的影响：比值比（OR）= 2.21（95%置信区间[CI] = 1.39 - 3.50）。这种关联在老年参与者（50 - 82岁）中消失。
数据表明，尤其是患有MDD的年轻（可能是绝经前）女性比未患重度抑郁症的女性更有可能患MetS，并且年龄会减弱这种关联。
