Russo Daniela, Rea Giuseppina, Lambreva Maya D, Haertlein Michael, Moulin Martine, De Francesco Alessio, Campi Gaetano
CNR Istituto Officina dei Materiali c/o Institut Laue Langevin , 38042 Grenoble, France.
Institut Lumière Matière, Université de Lyon 1 , 69100 Lyon, France.
J Phys Chem Lett. 2016 Jul 7;7(13):2429-33. doi: 10.1021/acs.jpclett.6b00949. Epub 2016 Jun 16.
In the context of the importance of water molecules for protein function/dynamics relationship, the role of water collective dynamics in Chlamydomonas green algae carrying both native and mutated photosynthetic proteins has been investigated by neutron Brillouin scattering spectroscopy. Results show that single point genetic mutation may notably affect collective density fluctuations in hydrating water providing important insight on the transmission of information possibly correlated to biological functionality. In particular, we highlight that the damping factor of the excitations is larger in the native compared to the mutant algae as a signature of a different plasticity and structure of the hydrogen bond network.
在水分子对蛋白质功能/动力学关系的重要性背景下，通过中子布里渊散射光谱研究了水的集体动力学在携带天然和突变光合蛋白的衣藻绿藻中的作用。结果表明，单点基因突变可能显著影响水合水中的集体密度涨落，为可能与生物功能相关的信息传递提供了重要见解。特别是，我们强调，与突变藻类相比，天然藻类中激发的阻尼因子更大，这是氢键网络不同可塑性和结构的一个特征。
