Chou Ping-Song, Hsu Chung-Yao, Wu Meng-Ni, Liou Li-Min, Lu Shinag-Ru, Liu Ching-Kuan, Lai Chiou-Lian
Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
PLoS One. 2016 Jun 14;11(6):e0157575. doi: 10.1371/journal.pone.0157575. eCollection 2016.
Obstructive sleep apnea (OSA) is associated with a broad range of frontal lobe dysfunctions. However, no study has investigated action monitoring, a crucial domain of frontal cognitive functions, in patients with OSA. By using the modified Flanker task, we tested the hypothesis that patients with OSA have an impaired action monitoring function. We recruited 25 untreated patients with moderate-severe OSA and 12 control participants who were matched for age, sex, apolipoprotein E4, and education level. Every enrolled participant underwent a standard overnight laboratory-based polysomnography and completed a modified Flanker task. Compared with the controls, the patients with OSA presented a significantly lower correct response rate in all trials (78.9% vs 95.9%, P = .008), congruent trials (84.7% vs 98.3%, P = .016), and incongruent trials (77.4% vs 94.7%, P = .009). The post-error correction rate was significantly lower in the patients with OSA than in the controls (74.9% vs 93.8%, P = .005). Furthermore, strong significant correlations were observed between the arousal index and correct rate in all trials (r = -0.390, P < .05) and in the incongruent trials (r = -0.429, P < .01), as well as between the arousal index and rate of post-error correction (r = -0.435, P < .01). We concluded that the action monitoring function was impaired in the patients with OSA. Sleep fragmentation was a major determinant of impaired action monitoring in these patients.
阻塞性睡眠呼吸暂停（OSA）与广泛的额叶功能障碍有关。然而，尚无研究调查OSA患者的动作监测，这是额叶认知功能的一个关键领域。通过使用改良的侧翼任务，我们检验了OSA患者动作监测功能受损的假设。我们招募了25名未经治疗的中重度OSA患者和12名年龄、性别、载脂蛋白E4和教育水平相匹配的对照参与者。每位入选参与者均接受了基于实验室的标准过夜多导睡眠图检查，并完成了改良的侧翼任务。与对照组相比，OSA患者在所有试验（78.9%对95.9%，P = 0.008）、一致性试验（84.7%对98.3%，P = 0.016）和不一致性试验（77.4%对94.7%，P = 0.009）中的正确反应率显著较低。OSA患者的错误后校正率显著低于对照组（74.9%对93.8%，P = 0.005）。此外，在所有试验（r = -0.390，P < 0.05）和不一致性试验（r = -0.429，P < 0.01）中，觉醒指数与正确率之间，以及觉醒指数与错误后校正率之间均观察到强显著相关性（r = -0.435，P < 0.01）。我们得出结论，OSA患者的动作监测功能受损。睡眠片段化是这些患者动作监测受损的主要决定因素。
