Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Montreal, Québec, Canada.
Sleep Med. 2013 Jul;14(7):685-7. doi: 10.1016/j.sleep.2013.03.014. Epub 2013 May 18.
Sleepiness, cognitive deficits, abnormal event-related potentials (ERP), and slowing of the waking electroencephalography (EEG) activity have been reported in patients with obstructive sleep apnea (OSA). Our study aimed at evaluating if an association exists between the severity of ERP abnormalities and EEG slowing to better understand cerebral dysfunctions in OSA.
Twelve OSA patients and 12 age-matched controls underwent an overnight polysomnographic recording, an EEG recording of 10 min of wakefulness, and an auditory ERP protocol known to specifically recruit attention. P300 and P3a ERP components were measured as well as the spectral power in each frequency band of the waking EEG. Pearson product moment correlations were used to measure associations between ERP characteristics and EEG spectral power in OSA patients and control subjects.
A positive correlation between the late P300 amplitude and θ power in the occipital region was observed in OSA subjects (P<.01). A positive correlation was also found between P3a amplitude and β1 power in central region in OSA subjects (P<.01). No correlation was observed for control subjects.
ERP abnormalities observed in an attention task are associated with a slowing of the waking EEG recorded at rest in OSA.
阻塞性睡眠呼吸暂停（OSA）患者存在嗜睡、认知障碍、异常事件相关电位（ERP）和清醒脑电图（EEG）活动减慢等情况。我们的研究旨在评估 ERP 异常严重程度与 EEG 减慢之间是否存在关联，以更好地了解 OSA 中的脑功能障碍。
12 名 OSA 患者和 12 名年龄匹配的对照组接受了一整晚的多导睡眠图记录、10 分钟清醒期的 EEG 记录以及已知专门募集注意力的听觉 ERP 方案。测量了 P300 和 P3a ERP 成分以及清醒 EEG 各频段的频谱功率。使用 Pearson 积矩相关来测量 OSA 患者和对照组中 ERP 特征与 EEG 频谱功率之间的相关性。
在 OSA 受试者中，观察到晚期 P300 振幅与枕区θ功率之间存在正相关（P<.01）。在 OSA 受试者的中央区域也观察到 P3a 振幅与β1 功率之间存在正相关（P<.01）。对照组未观察到相关性。
在注意力任务中观察到的 ERP 异常与 OSA 患者在休息时记录的清醒 EEG 减慢有关。
