非甾体抗炎药和疾病活动度对类风湿关节炎、骨关节炎和风湿性多肌痛患者血清碱性磷酸酶浓度的影响。
Influence of non-steroidal anti-inflammatory drugs and disease activity on serum alkaline phosphatase concentrations in rheumatoid arthritis, osteoarthritis, and polymyalgia rheumatica.
作者信息
Doube A, Davies J, Davis M, Maddison P J
机构信息
Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, Bath.
出版信息
Ann Rheum Dis. 1989 May;48(5):368-71. doi: 10.1136/ard.48.5.368.
The influence of non-steroidal anti-inflammatory drugs (NSAIDs) and of disease activity on the serum alkaline phosphatase concentration was examined in patients with rheumatoid arthritis, osteoarthritis, and polymyalgia rheumatica. Concentrations of serum alkaline phosphatase were similar both in patients with rheumatoid arthritis taking NSAIDs and in those not taking NSAIDs. In patients with osteoarthritis NSAID use was not associated with a significant increase in serum alkaline phosphatase. In rheumatoid arthritis no correlation was found between clinical indices of disease activity and serum alkaline phosphatase concentrations. There was significant correlation with plasma viscosity in rheumatoid arthritis, both in those taking and not taking NSAIDs, and in polymyalgia rheumatica. Serum alkaline phosphatase concentrations are not influenced by NSAIDs. Concentrations correlate with laboratory parameters, but not clinical indices of disease activity.
在类风湿关节炎、骨关节炎和风湿性多肌痛患者中，研究了非甾体抗炎药（NSAIDs）和疾病活动度对血清碱性磷酸酶浓度的影响。服用NSAIDs的类风湿关节炎患者与未服用NSAIDs的患者血清碱性磷酸酶浓度相似。在骨关节炎患者中，使用NSAIDs与血清碱性磷酸酶显著升高无关。在类风湿关节炎中，未发现疾病活动度的临床指标与血清碱性磷酸酶浓度之间存在相关性。在类风湿关节炎中，无论是否服用NSAIDs，以及在风湿性多肌痛中，血清碱性磷酸酶浓度与血浆粘度均存在显著相关性。血清碱性磷酸酶浓度不受NSAIDs影响。其浓度与实验室参数相关，但与疾病活动度的临床指标无关。
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