Reite M, Teale P, Goldstein L, Whalen J, Linnville S
Department of Psychiatry, University of Colorado Health Sciences Center, Denver 80262.
Arch Gen Psychiatry. 1989 Jun;46(6):565-72. doi: 10.1001/archpsyc.1989.01810060087013.
We recorded magnetoencephalographic auditory evoked fields from the left and right hemispheres of six medicated, paranoid schizophrenic subjects and six normal controls. The magnetic field data were used in estimating the location, orientation, and depth of the source generating the 100-millisecond latency evoked field component (M100). The M100 latencies were slightly shorter than simultaneously recorded vertex electroencephalographic evoked potential N100 latencies, suggesting that magnetoencephalographic and electroencephalographic recordings were examining slightly different aspects of the source(s). The M100 sources demonstrated substantial interhemispheric asymmetry in normal controls, and were located more posteriorly, with more nearly vertical orientations, over the left hemisphere. The M100 sources in schizophrenics did not exhibit the same interhemispheric asymmetry. Left hemisphere source orientation differed significantly between normal controls and schizophrenics. Discriminant function analysis correctly classified normal controls and schizophrenics at 100% using the conservative jackknife procedure on the basis of left hemisphere orientation alone. Our findings, while preliminary, support altered left hemisphere function, or possibly structure, in this group of schizophrenic subjects, and suggest that magnetoencephalographic recordings may be a useful research method in this major mental illness.
我们记录了6名服用药物的偏执型精神分裂症患者和6名正常对照者左右半球的脑磁图听觉诱发电场。磁场数据用于估计产生100毫秒潜伏期诱发电场成分（M100）的源的位置、方向和深度。M100潜伏期比同时记录的头顶脑电图诱发电位N100潜伏期略短，这表明脑磁图和脑电图记录检查的是源的略有不同的方面。M100源在正常对照者中表现出明显的半球间不对称，并且在左半球上位于更靠后的位置，方向更接近垂直。精神分裂症患者的M100源没有表现出相同的半球间不对称。正常对照者和精神分裂症患者的左半球源方向存在显著差异。判别函数分析仅基于左半球方向，使用保守的留一法程序，正确地将正常对照者和精神分裂症患者分类为100%。我们的研究结果虽然是初步的，但支持这组精神分裂症患者左半球功能或可能结构的改变，并表明脑磁图记录可能是这种主要精神疾病的一种有用的研究方法。
