Reite M, Sheeder J, Teale P, Adams M, Richardson D, Simon J, Jones R H, Rojas D C
Departments of Psychiatry, University of Colorado Health Sciences Center, Denver, USA.
Arch Gen Psychiatry. 1997 May;54(5):433-40. doi: 10.1001/archpsyc.1997.01830170059009.
It has been postulated that schizophrenia represents a disorder of anomalous cerebral lateralization. This study is a replication of earlier preliminary findings using a multichannel neuromagnetometer, suggesting altered lateralization in schizophrenia in male subjects, with an extension of the findings to female subjects.
We used magnetoencephalography-based magnetic source imaging to estimate the intracranial location of the 100-millisecond latency auditory-evoked field component (M100) in both left and right hemispheres of 20 patients with paranoid schizophrenia and 20 controls without schizophrenia. Neuroanatomical data were obtained by means of magnetic resonance imaging, from which we segmented and computed volumes of both total brain and left and right superior temporal gyri.
Locations of M100 source were compatible with neuronal generators located in the transverse gyri of Heschl on the superior temporal gyri in both study groups; M100 sources were asymmetric in all the control subjects. The male patient subgroup exhibited significantly less asymmetry than the control group, while the female patient subgroup actually showed significantly more asymmetry. The male patient subgroup generally had smaller superior temporal gyri than the control group. No evidence of total brain volume differences was observed.
Our findings support previous magnetoencephalography-based studies suggesting anomalous cerebral lateralization in schizophrenia. Further, in extending our studies to female patients, our data suggest that the nature of this anomaly is sex specific, a finding that, to our knowledge, has not previously been reported.
据推测，精神分裂症是一种大脑异常偏侧化的疾病。本研究是对早期初步研究结果的重复，早期研究使用多通道神经磁强计，提示男性精神分裂症患者存在偏侧化改变，本研究将结果扩展至女性患者。
我们使用基于脑磁图的磁源成像来估计20例偏执型精神分裂症患者和20例无精神分裂症对照者左右半球100毫秒潜伏期听觉诱发电场成分（M100）的颅内位置。通过磁共振成像获得神经解剖学数据，从中我们分割并计算了全脑以及左右颞上回的体积。
两个研究组中M100源的位置与位于颞上回Heschl横回的神经元发生器一致；所有对照者的M100源均不对称。男性患者亚组的不对称性明显低于对照组，而女性患者亚组实际上表现出明显更高的不对称性。男性患者亚组的颞上回通常比对照组小。未观察到全脑体积差异的证据。
我们的研究结果支持先前基于脑磁图的研究，提示精神分裂症存在大脑异常偏侧化。此外，在将我们的研究扩展至女性患者时，我们的数据表明这种异常的性质具有性别特异性，据我们所知，这一发现此前尚未见报道。
