内部黑客！嗜吞噬细胞无形体效应器驱动的吞噬细胞重编程策略。
Hacker within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy.
作者信息
Lina Taslima T, Farris Tierra, Luo Tian, Mitra Shubhajit, Zhu Bing, McBride Jere W
机构信息
Department of Pathology, University of Texas Medical Branch Galveston, TX, USA.
Department of Pathology, University of Texas Medical BranchGalveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical BranchGalveston, TX, USA; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical BranchGalveston, TX, USA; Sealy Center for Vaccine Development, University of Texas Medical BranchGalveston, TX, USA; Institute for Human Infections and Immunity, University of Texas Medical BranchGalveston, TX, USA.
出版信息
Front Cell Infect Microbiol. 2016 May 31;6:58. doi: 10.3389/fcimb.2016.00058. eCollection 2016.
Ehrlichia chaffeensis is a small, gram negative, obligately intracellular bacterium that preferentially infects mononuclear phagocytes. It is the etiologic agent of human monocytotropic ehrlichiosis (HME), an emerging life-threatening tick-borne zoonosis. Mechanisms by which E. chaffeensis establishes intracellular infection, and avoids host defenses are not well understood, but involve functionally relevant host-pathogen interactions associated with tandem and ankyrin repeat effector proteins. In this review, we discuss the recent advances in our understanding of the molecular and cellular mechanisms that underlie Ehrlichia host cellular reprogramming strategies that enable intracellular survival.
查菲埃立克体是一种小型革兰氏阴性专性细胞内细菌，优先感染单核吞噬细胞。它是人类单核细胞埃立克体病（HME）的病原体，HME是一种新出现的、危及生命的蜱传人畜共患病。查菲埃立克体建立细胞内感染并逃避宿主防御的机制尚未完全了解，但涉及与串联和锚蛋白重复效应蛋白相关的功能相关的宿主-病原体相互作用。在这篇综述中，我们讨论了我们对埃立克体宿主细胞重编程策略背后的分子和细胞机制的最新理解进展，这些策略使细胞内生存成为可能。
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