靶向去势抵抗性前列腺癌中的己糖激酶2
Targeting hexokinase 2 in castration-resistant prostate cancer.
作者信息
Deng Yibin, Lu Junxuan
机构信息
Laboratory of Cancer Genetics; The University of Minnesota Hormel Institute ; Austin, MN USA.
Department of Biomedical Sciences; Texas Tech University Health Sciences Center School of Pharmacy ; Amarillo, TX USA.
出版信息
Mol Cell Oncol. 2015 Apr 30;2(3):e974465. doi: 10.4161/23723556.2014.974465. eCollection 2015 Jul-Sep.
Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.
有氧糖酵解，即著名的瓦伯格效应，是癌细胞的特征之一。我们最近报道，由Pten/p53缺陷驱动的去势抵抗性前列腺癌需要己糖激酶2（HK2）介导的瓦伯格效应，这表明HK2可能是携带PTEN和p53突变的前列腺癌患者的治疗靶点。
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