Zhao Junpeng, Jin Dandan, Huang Mengxiang, Ji Jie, Xu Xuebing, Wang Fei, Zhou Lirong, Bao Baijun, Jiang Feng, Xu Weisong, Lu Xiaomin, Xiao Mingbing
Department of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Department of Laboratory Medicine, Affiliated Hospital and Medical School of Nantong University, Nantong, Jiangsu, China.
Front Cell Dev Biol. 2024 Jun 12;12:1416472. doi: 10.3389/fcell.2024.1416472. eCollection 2024.
Even with sufficient oxygen, tumor cells use glycolysis to obtain the energy and macromolecules they require to multiply, once thought to be a characteristic of tumor cells known as the "Warburg effect". In fact, throughout the process of carcinogenesis, immune cells and stromal cells, two major cellular constituents of the tumor microenvironment (TME), also undergo thorough metabolic reprogramming, which is typified by increased glycolysis. In this review, we provide a full-scale review of the glycolytic remodeling of several types of TME cells and show how these TME cells behave in the acidic milieu created by glucose shortage and lactate accumulation as a result of increased tumor glycolysis. Notably, we provide an overview of putative targets and inhibitors of glycolysis along with the viability of using glycolysis inhibitors in combination with immunotherapy and chemotherapy. Understanding the glycolytic situations in diverse cells within the tumor immunological milieu will aid in the creation of subsequent treatment plans.
即使在氧气充足的情况下，肿瘤细胞也会利用糖酵解来获取增殖所需的能量和大分子物质，这曾被认为是肿瘤细胞的一种特性，即“瓦伯格效应”。事实上，在整个致癌过程中，肿瘤微环境（TME）的两个主要细胞成分，即免疫细胞和基质细胞，也会经历彻底的代谢重编程，其典型特征是糖酵解增加。在这篇综述中，我们全面回顾了几种类型的TME细胞的糖酵解重塑，并展示了这些TME细胞在肿瘤糖酵解增加导致的葡萄糖短缺和乳酸积累所形成的酸性环境中的行为。值得注意的是，我们概述了糖酵解的假定靶点和抑制剂，以及将糖酵解抑制剂与免疫疗法和化疗联合使用的可行性。了解肿瘤免疫环境中不同细胞的糖酵解情况将有助于制定后续的治疗方案。
