新染色体的生活史被揭示。
The life history of neochromosomes revealed.
作者信息
Papenfuss Anthony T, Thomas David M
机构信息
Bioinformatics Division; The Walter & Eliza Hall Institute of Medical Research; Parkville, Australia; Peter MacCallum Cancer Centre; East Melbourne, Australia; Department of Medical Biology; University of Melbourne; Melbourne, Australia; Sir Peter MacCallum Department of Oncology; University of Melbourne; Melbourne, Australia.
Peter MacCallum Cancer Centre; East Melbourne, Australia; The Kinghorn Cancer Centre, Garvan Institute of Medical Research; Sydney, Australia; University of New South Wales; Sydney, Australia.
出版信息
Mol Cell Oncol. 2015 Jan 23;2(4):e1000698. doi: 10.1080/23723556.2014.1000698. eCollection 2015 Oct-Dec.
Neochromosomes are a little-studied class of chromosome-scale mutations that drive some cancers. By sequencing isolated neochromosomes from liposarcomas, we recently defined their structure at single-nucleotide resolution and proposed a model for their life history. Here, we summarize that work, highlighting significant aspects and providing historical context and insight into the discovery process.
新染色体是一类研究较少的染色体规模突变，可引发某些癌症。通过对脂肪肉瘤中分离出的新染色体进行测序，我们最近在单核苷酸分辨率下确定了它们的结构，并提出了一个关于其生命史的模型。在这里，我们总结这项工作，突出重要方面，并提供历史背景以及对发现过程的见解。
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