模型类器官为胰腺导管癌提供了新的研究机会。
Model organoids provide new research opportunities for ductal pancreatic cancer.
作者信息
Boj Sylvia F, Hwang Chang-Il, Baker Lindsey A, Engle Dannielle D, Tuveson David A, Clevers Hans
机构信息
Hubrecht Institute; Royal Netherlands Academy of Arts and Sciences (KNAW); University Medical Center Utrecht and Cancer Genomics; Utrecht, the Netherlands; Foundation Hubrecht Organoid Technology; Utrecht, the Netherlands.
Cold Spring Harbor Laboratory; Cold Spring Harbor, NY USA; Lustgarten Foundation Pancreatic Cancer Research Laboratory; Cold Spring Harbor, NY USA.
出版信息
Mol Cell Oncol. 2015 Feb 23;3(1):e1014757. doi: 10.1080/23723556.2015.1014757. eCollection 2016 Jan.
Abstract
We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.
摘要
我们最近从正常和肿瘤性小鼠及人类胰腺组织中建立了类器官模型。这些类器官表现出导管和疾病阶段特异性特征，并且在原位移植后，概括了肿瘤进展的全谱。胰腺类器官技术为肿瘤生物学研究以及潜在生物标志物、治疗方法和个性化医学策略的发现提供了一个新平台。
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