Moreira Leticia, Bakir Basil, Chatterji Priya, Dantes Zahra, Reichert Maximilian, Rustgi Anil K
Division of Gastroenterology, Departments of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Department of Gastroenterology, Hospital Clínic, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas, IDIBAPS, University of Barcelona, Catalonia, Spain.
Cell Mol Gastroenterol Hepatol. 2017 Dec 16;5(3):289-298. doi: 10.1016/j.jcmgh.2017.12.004. eCollection 2018 Mar.
Pancreatic ductal adenocarcinoma is one of the most aggressive forms of cancer, and the third leading cause of cancer-related mortality in the United States. Although important advances have been made in the last decade, the mortality rate of pancreatic ductal adenocarcinoma has not changed appreciably. This review summarizes a rapidly emerging model of pancreatic cancer research, focusing on 3-dimensional organoids as a powerful tool for several applications, but above all, representing a step toward personalized medicine.
胰腺导管腺癌是最具侵袭性的癌症形式之一,也是美国癌症相关死亡的第三大主要原因。尽管在过去十年中取得了重要进展,但胰腺导管腺癌的死亡率并未明显改变。本综述总结了一种迅速兴起的胰腺癌研究模式,重点关注三维类器官,它作为一种强大的工具可用于多种应用,但最重要的是,它代表了迈向个性化医疗的一步。