Marin Maria C, Marques Margarita M
Instituto de Biomedicina and Departmento de Biologia Molecular; University of Leon ; Leon, Spain.
Instituto de Desarrollo Ganadero; University of Leon ; Leon, Spain.
Mol Cell Oncol. 2015 May 26;3(1):e1019973. doi: 10.1080/23723556.2015.1019973. eCollection 2016 Jan.
Information regarding the role of p73 in the regulation of angiogenesis has been incomplete and quite controversial. Remarkably, several groups, including ours, have recently demonstrated that TP73 plays a fundamental role in angiogenesis regulation and that differential expression of TP73 could have important consequences in tumor angiogenesis. Here, we discuss a possible model for p73 function in the regulation of developmental angiogenesis and tumor angiogenesis.
关于p73在血管生成调节中的作用的信息一直不完整且颇具争议。值得注意的是，包括我们在内的几个研究小组最近证明，TP73在血管生成调节中起基本作用，并且TP73的差异表达可能在肿瘤血管生成中产生重要影响。在此，我们讨论p73在发育性血管生成和肿瘤血管生成调节中的功能的一种可能模型。
