Herraiz Cecilia, Crosas-Molist Eva, Sanz-Moreno Victoria
Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London , London SE1 1UL, UK.
Mol Cell Oncol. 2016 Jan 19;3(2):e1127313. doi: 10.1080/23723556.2015.1127313. eCollection 2016 Mar.
For decades, reactive oxygen species (ROS) linked to oxidative stress have been suggested to promote carcinogenesis. However, we and others have demonstrated a protective role for ROS in metastatic dissemination. These recent studies partly explain the large failure observed in clinical trials using antioxidants for cancer prevention.
数十年来，与氧化应激相关的活性氧（ROS）一直被认为会促进癌症发生。然而，我们和其他研究人员已证明ROS在肿瘤转移扩散中具有保护作用。这些最新研究部分解释了在使用抗氧化剂预防癌症的临床试验中所观察到的大量失败案例。
