Carter S D, Makh S R, Ponsford F M, Elson C J
Department of Pathology, University of Bristol.
Br J Rheumatol. 1989 Jun;28(3):233-8. doi: 10.1093/rheumatology/28.3.233.
Synovial fluid IgG may be altered in rheumatoid arthritis (RA) and promote the formation of immune complexes with rheumatoid factor. To investigate this possibility, monomeric IgG was prepared from synovial fluids from a range of arthritides for use as the antigen in a rheumatoid factor microplate radioimmunoassay. In comparisons with normal serum IgG antigen, increased rheumatoid factor binding was shown to IgG antigens prepared from synovial fluids from patients with RA and osteoarthritis (OA). Increased binding was also shown to RA sera IgG, but not to OA sera IgG. This increased binding was not due to increased IgG antigen binding to the plate or to IgG rheumatoid factor in the antigen preparations. It was considered that cause was a structural alteration of the IgG as a result of inflammation within the rheumatoid and OA joint.
类风湿关节炎（RA）患者的滑液免疫球蛋白G（IgG）可能会发生改变，并促进与类风湿因子形成免疫复合物。为了研究这种可能性，从一系列关节炎患者的滑液中制备了单体IgG，用作类风湿因子微孔板放射免疫分析中的抗原。与正常血清IgG抗原相比，类风湿关节炎（RA）和骨关节炎（OA）患者滑液制备的IgG抗原显示出类风湿因子结合增加。类风湿关节炎血清IgG也显示出结合增加，但骨关节炎血清IgG则未显示。这种结合增加并非由于IgG抗原与板的结合增加，也不是由于抗原制剂中的IgG类风湿因子增加。据认为，原因是类风湿关节炎和骨关节炎关节内炎症导致IgG结构改变。
