Fairney A, Patel K V, Hollings N P, Seifert M H
St Mary's Hospital and Medical School, London.
Ann Rheum Dis. 1990 Apr;49(4):229-30. doi: 10.1136/ard.49.4.229.
Studies of osteocalcin in the serum and synovial fluid of patients with rheumatoid arthritis (RA) and osteoarthritis (OA) showed the presence of significant amounts of osteocalcin in synovial fluid and that the values in RA synovial fluid were significantly lower than in OA synovial fluid. In addition, the osteocalcin in OA synovial fluid bound almost completely to hydroxyapatite, whereas a significant proportion of the osteocalcin in RA synovial fluid did not. These studies suggest that patients with severe RA produce low amounts of active osteocalcin and higher than expected amounts of inactive osteocalcin in the synovial fluid. They provide some evidence that osteoblast function may be abnormal in the osteoporosis of RA.
对类风湿性关节炎（RA）和骨关节炎（OA）患者血清及滑液中骨钙素的研究表明，滑液中存在大量骨钙素，且RA滑液中的骨钙素值显著低于OA滑液中的骨钙素值。此外，OA滑液中的骨钙素几乎完全与羟基磷灰石结合，而RA滑液中有相当一部分骨钙素并未结合。这些研究表明，重症RA患者滑膜液中活性骨钙素产生量低，非活性骨钙素产生量高于预期。它们提供了一些证据，表明RA骨质疏松症中，成骨细胞功能可能异常。
