Conway Baqiyyah, Innes Karen E, Long Dustin
Department of Epidemiology, West Virginia University, P.O. Box 9127, Morgantown, WV 26505.
Department of Epidemiology, West Virginia University, P.O. Box 9127, Morgantown, WV 26505.
J Diabetes Complications. 2016 Aug;30(6):993-8. doi: 10.1016/j.jdiacomp.2016.05.001. Epub 2016 May 4.
Perfluoroalkyl substances (PFAS) are synthetic hydrocarbons shown to preserve pancreatic islet cell viability and reduce islet cell hypoxia and apoptosis. We investigated the relationship of serum PFAS with diabetes, and whether this varied by diabetes type.
6,460 individuals with and 60,439 without diabetes from the C8 Health Project, were categorized into three groups: type 1 (n=820), type 2 (n=4,291), or uncategorized diabetes (n=1,349, missing data on diabetes type or diabetes based on blood sugar at study entry). Four PFAS were investigated: perfluorohexane sulfonate (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), and perfluorononaoic acid (PFNA).
PFAS levels were significantly lower in those with diabetes, and lowest in those with type 1 diabetes. In age and sex adjusted analyses, ORs (CI) for type 1, type 2, and uncategorized diabetes compared to no diabetes were 0.59 (0.54-0.64), 0.74 (0.71-0.77), 0.84 (0.78-0.90), respectively for PFHxS; 0.69 (0.65-0.74), 0.87 (0.89-0.91), 0.92 (0.88-0.97), respectively for PFOA; 0.65 (0.61-0.70), 0.86 (0.82-0.90), 0.93 (0.86-1.03), respectively for PFOS; and 0.65 (0.57-0.74), 0.94 (0.88-1.00), 0.95 (0.85-1.06), respectively for PFNA. Further adjustment for eGFR and other covariates did not eliminate these inverse associations.
PFAS levels were negatively associated with diabetes. This inverse relationship was strongest for type 1 diabetes, suggesting the relationship with serum PFAS may vary with the severity of islet cell deficiency.
全氟烷基物质（PFAS）是一类合成碳氢化合物，已被证明可维持胰岛细胞活力，减少胰岛细胞缺氧和凋亡。我们研究了血清PFAS与糖尿病的关系，以及这种关系是否因糖尿病类型而异。
来自C8健康项目的6460名糖尿病患者和60439名非糖尿病患者被分为三组：1型糖尿病（n = 820）、2型糖尿病（n = 4291）或未分类糖尿病（n = 1349，研究入组时糖尿病类型或基于血糖的糖尿病数据缺失）。研究了四种PFAS：全氟己烷磺酸（PFHxS）、全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）和全氟壬酸（PFNA）。
糖尿病患者的PFAS水平显著较低，1型糖尿病患者的PFAS水平最低。在年龄和性别调整分析中，与无糖尿病相比，PFHxS的1型、2型和未分类糖尿病的OR（CI）分别为0.59（0.54 - 0.64）、0.74（0.71 - 0.77）、0.84（0.78 - 0.90）；PFOA的分别为0.69（0.65 - 0.74）、0.87（0.89 - 0.91）、0.92（0.88 - 0.97）；PFOS的分别为0.65（0.61 - 0.70）、0.86（0.82 - 0.90）、0.93（0.86 - 1.03）；PFNA的分别为0.65（0.57 - 0.74）、0.94（0.88 - 1.00）、0.95（0.85 - 1.06）。进一步调整估算肾小球滤过率（eGFR）和其他协变量并未消除这些负相关关系。
PFAS水平与糖尿病呈负相关。这种负相关关系在1型糖尿病中最为明显，表明与血清PFAS的关系可能随胰岛细胞缺乏的严重程度而变化。
