Stein Cheryl R, Savitz David A, Elston Beth, Thorpe Phoebe G, Gilboa Suzanne M
Department of Preventive Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1057, New York, NY 10029-6574, United States.
Department of Epidemiology, Brown University School of Public Health, Providence, RI, United States.
Reprod Toxicol. 2014 Aug;47:15-20. doi: 10.1016/j.reprotox.2014.04.006. Epub 2014 May 4.
Perfluorooctanoate (PFOA) is detectable in umbilical cord blood and amniotic fluid. Some toxicological findings suggest that perfluoroalkyl substances may be teratogenic. Using data from the C8 Health Project, a 2005-2006 survey in a Mid-Ohio Valley community exposed to PFOA through contaminated drinking water, we examined the association between estimated prenatal PFOA concentration and maternally reported birth defects (n=325) among 10,262 live singleton or multiple births from 1990 to 2006. Logistic regression models accounted for siblings using generalized estimating equations. There was generally no association between estimated PFOA concentration and birth defects, with the possible exception of brain defects, where the odds ratio adjusted for year of conception was 2.6 (95% confidence interval 1.3-5.1) for an increase in estimated PFOA exposure from the 25th to 75th percentile. This estimate, however, was based on 13 cases and may represent a chance finding. Further investigation of this potential association may be warranted.
全氟辛酸（PFOA）可在脐带血和羊水中检测到。一些毒理学研究结果表明，全氟烷基物质可能具有致畸性。利用C8健康项目的数据，该项目是2005 - 2006年对俄亥俄州中部山谷一个通过受污染饮用水接触PFOA的社区进行的调查，我们研究了1990年至2006年期间10262例单胎或多胎活产中估计的产前PFOA浓度与母亲报告的出生缺陷（n = 325）之间的关联。逻辑回归模型使用广义估计方程对兄弟姐妹进行了分析。一般来说，估计的PFOA浓度与出生缺陷之间没有关联，但脑缺陷可能是个例外，对于估计的PFOA暴露从第25百分位数增加到第75百分位数的情况，经受孕年份调整后的优势比为2.6（95%置信区间1.3 - 5.1）。然而，这一估计是基于13例病例，可能只是偶然发现。对此潜在关联进行进一步调查可能是有必要的。
