Berg Vivian, Charles Dolley D, Huber Sandra, Nøst Therese H, Sandanger Torkjel M, Averina Maria, Bergdahl Ingvar A, Nilsen Mia M, Wilsgaard Tom, Rylander Charlotta
Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, Stakkevollan, P.O Box 6050, 9037, Tromsø, Norway.
Department of Laboratory Medicine, University Hospital of North-Norway, Tromsø, Norway.
Sci Rep. 2025 Jul 1;15(1):22026. doi: 10.1038/s41598-025-05422-1.
We assessed temporal changes of PFAS and associations with T2DM over a period of 30 years in a nested case-control study with repeated measurements. Logistic regression was used to assess associations between 11 PFAS and T2DM at five time-points in 116 cases and 139 controls (3 pre- and 2 post-diagnostic time-points in cases). Mixed linear models were applied to assess if changes in PFAS were related to T2DM status. In the pre-diagnostic time-point T3 (2001), future cases had higher concentrations of PFHpA, PFNA, PFHxS and PFHpS compared to controls. In the post-diagnostic time point T5 (2015/16), PFNA and PFOS were higher in prevalent cases. PFHxS and PFHpS were positively associated with future T2DM at the pre-diagnostic time-point T3, whereas PFTrDA were inversely associated with future T2DM at T1 (1986/87) and prevalent T2DM at T4 (2007/8). Temporal changes in PFAS across the study period showed that cases experienced a greater increase in pre-diagnostic concentrations of PFHpA, PFTrDA, PFHxS and PFOSA, as well as a larger post-diagnostic decrease in PFOSA, compared to controls. This study is the first to show that temporal changes in PFAS are associated with T2DM status for certain PFAS, and associations between PFAS and T2DM vary according to sample year.
在一项进行了重复测量的巢式病例对照研究中，我们评估了30年间全氟和多氟烷基物质（PFAS）的时间变化及其与2型糖尿病（T2DM）的关联。采用逻辑回归分析116例病例和139例对照在五个时间点（病例的3个诊断前和2个诊断后时间点）中11种PFAS与T2DM之间的关联。应用混合线性模型评估PFAS的变化是否与T2DM状态相关。在诊断前时间点T3（2001年），与对照相比，未来的病例中全氟庚酸（PFHpA）、全氟萘酸（PFNA）、全氟己烷磺酸（PFHxS）和全氟己基磺酸（PFHpS）的浓度更高。在诊断后时间点T5（2015/16年），现患病例中PFNA和全氟辛烷磺酸（PFOS）的浓度更高。PFHxS和PFHpS在诊断前时间点T3与未来的T2DM呈正相关，而全氟十三烷酸（PFTrDA）在T1（1986/87年）与未来的T2DM以及在T4（2007/8年）与现患T2DM呈负相关。整个研究期间PFAS的时间变化表明，与对照相比，病例在诊断前PFHpA、PFTrDA、PFHxS和全氟辛烷磺酸（PFOSA）浓度的增加幅度更大，以及在诊断后PFOSA的下降幅度更大。本研究首次表明，某些PFAS的时间变化与T2DM状态相关，且PFAS与T2DM之间的关联因样本年份而异。
