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Lost in Translation: CRF1 Receptor Antagonists and Addiction Treatment.

作者信息

Shaham Yavin, de Wit Harriet

机构信息

Behavioral Neuroscience Branch, IRP-NIDA, NIH, Baltimore, MD, USA.

Department of Psychiatry and Behavioral Neuroscience, University of Chicago, IL, USA.

出版信息

Neuropsychopharmacology. 2016 Nov;41(12):2795-2797. doi: 10.1038/npp.2016.94.

DOI:10.1038/npp.2016.94
PMID:27312404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5061894/
Abstract
摘要

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The CRF1 Antagonist Verucerfont in Anxious Alcohol-Dependent Women: Translation of Neuroendocrine, But not of Anti-Craving Effects.CRF1拮抗剂维鲁塞丰对焦虑型酒精依赖女性的作用：神经内分泌作用的转化，但非抗渴望作用的转化
Neuropsychopharmacology. 2016 Nov;41(12):2818-2829. doi: 10.1038/npp.2016.61. Epub 2016 Apr 25.
3
Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress.应激诱导的觅药行为恢复：20年的进展
Neuropsychopharmacology. 2016 Jan;41(1):335-56. doi: 10.1038/npp.2015.142. Epub 2015 May 15.
4
The CRH1 antagonist GSK561679 increases human fear but not anxiety as assessed by startle.促肾上腺皮质激素释放激素1（CRH1）拮抗剂GSK561679会增加人类的恐惧，但通过惊吓反应评估发现它不会增加焦虑。
Neuropsychopharmacology. 2015 Mar 13;40(5):1064-71. doi: 10.1038/npp.2014.316.
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The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study.促肾上腺皮质激素释放激素-1（CRH1）受体拮抗剂培沙舍丰治疗酒精依赖：一项随机对照实验医学研究
Neuropsychopharmacology. 2015 Mar 13;40(5):1053-63. doi: 10.1038/npp.2014.306.
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Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism.针对酒精中毒治疗的 CRF(1) 受体拮抗剂的行为、生物和化学观点。
Drug Alcohol Depend. 2013 Mar 1;128(3):175-86. doi: 10.1016/j.drugalcdep.2012.12.017. Epub 2013 Jan 5.
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A systematic review of the relationships between craving and smoking cessation.一项关于渴望与戒烟关系的系统评价。
Nicotine Tob Res. 2013 Jul;15(7):1167-82. doi: 10.1093/ntr/nts268. Epub 2013 Jan 4.
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Binding kinetics redefine the antagonist pharmacology of the corticotropin-releasing factor type 1 receptor.结合动力学重新定义了促肾上腺皮质激素释放因子 1 型受体的拮抗剂药理学。
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Translational and reverse translational research on the role of stress in drug craving and relapse.应激在药物成瘾和复吸中的作用的转化和反向转化研究。
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The role of CRF and CRF-related peptides in the dark side of addiction.CRF 及相关肽在成瘾阴暗面中的作用。
Brain Res. 2010 Feb 16;1314:3-14. doi: 10.1016/j.brainres.2009.11.008. Epub 2009 Nov 11.