Leach Heather J, Danyluk Jessica M, Nishimura Kathryn C, Culos-Reed S Nicole
Department of Health and Exercise Science, Colorado State University, 951 Plum Street, Moby Complex B, Office 205D, Ft. Collins, CO, 80523, USA.
Faculty of Kinesiology, University of Calgary, 2500 University Dr. NW, Calgary, AB, T2N-1N4, Canada.
Support Care Cancer. 2016 Nov;24(11):4597-606. doi: 10.1007/s00520-016-3302-3. Epub 2016 Jun 16.
Community exercise programs can help maintain or improve health in cancer survivors. However, the most effective and feasible duration of a community exercise program for breast cancer survivors who are undergoing treatment is not known. This pre-post-design study evaluated the effects of the "Breast cancer patients Engaging in Activity while Undergoing Treatment" (BEAUTY) program on physical and psychosocial outcomes after 12 and 24 weeks.
BEAUTY is an ongoing community exercise and wellness program for breast cancer patients who are undergoing, or within 3 months of completing chemotherapy and radiation. Participants completed assessments at baseline, 12 weeks, and 24 weeks to measure body composition, hand-grip dynamometry, aerobic fitness, and flexibility. Self-report questionnaires assessed fatigue (FACIT-fatigue), cognitive function (FACT-cog), quality of life (QOL) (FACT-B), and depressive symptoms (CES-D). Main analyses were repeated measures general linear model for all outcomes.
Assessments at all three time points were completed by N = 63 participants. At 24 weeks, waist to hip ratio (p = .019), duration of the submaximal treadmill test (p = .013), and estimated VO2max (p = .018) improved compared to baseline. Fatigue improved at 24 compared to 12 weeks (p = .002). FACT-B scores improved at 24 weeks when compared to both baseline (p = .002) and 12 weeks (p = .001). Depressive symptoms improved compared to baseline (p = .05) and 12 weeks (p = .009).
Additional benefits were seen after 24 versus 12 weeks, suggesting that a longer duration exercise program during, or shortly after completing treatments for breast cancer, may be necessary to see improvements in fitness and psychosocial outcomes. Findings can be applied to community exercise and rehabilitation programs for breast cancer survivors.
社区锻炼计划有助于维持或改善癌症幸存者的健康状况。然而，对于正在接受治疗的乳腺癌幸存者而言，社区锻炼计划最有效且可行的时长尚不清楚。这项前后设计研究评估了“乳腺癌患者在治疗期间参与活动”（BEAUTY）计划在12周和24周后对身体和心理社会结局的影响。
BEAUTY是一项针对正在接受化疗和放疗或在完成化疗和放疗后3个月内的乳腺癌患者的持续社区锻炼与健康计划。参与者在基线、12周和24周时完成评估，以测量身体成分、握力测定、有氧适能和柔韧性。自我报告问卷评估疲劳（FACIT-疲劳）、认知功能（FACT-认知）、生活质量（QOL）（FACT-B）和抑郁症状（CES-D）。主要分析针对所有结局采用重复测量一般线性模型。
N = 63名参与者完成了所有三个时间点的评估。与基线相比，24周时腰臀比（p = 0.019）、次极量跑步机测试时长（p = 0.013）和估计的最大摄氧量（p = 0.018）有所改善。与12周相比，24周时疲劳有所改善（p = 0.002）。与基线（p = 0.002）和12周（p = 0.001）相比，FACT-B评分在24周时有所改善。与基线（p = 0.05）和12周（p = 0.009）相比，抑郁症状有所改善。
与12周相比，24周后出现了额外的益处，这表明在乳腺癌治疗期间或刚结束后进行更长时长锻炼计划，可能对于改善体能和心理社会结局是必要的。研究结果可应用于乳腺癌幸存者的社区锻炼和康复计划。
