钯催化实现α,α-二氟酮烯醇盐的苄基化反应。
Palladium Catalysis Enables Benzylation of α,α-Difluoroketone Enolates.
机构信息
Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS, 66045, USA.
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Science, 16 Azar St., Tehran, 1417614411, Iran.
出版信息
Angew Chem Int Ed Engl. 2016 Jul 25;55(31):9080-3. doi: 10.1002/anie.201604149. Epub 2016 Jun 17.
Abstract
A palladium-catalyzed decarboxylative benzylation reaction of α,α-difluoroketone enolates is reported, in which the key C(α)-C(sp(3) ) bond is generated by reductive elimination from a palladium intermediate. The transformation provides convergent access to α-benzyl-α,α-difluoroketone-based products, and should be useful for accessing biological probes.
摘要
本文报道了钯催化的α,α-二氟酮烯醇化物的脱羧苄基化反应，其中关键的 C(α)-C(sp(3) )键是通过钯中间体的还原消除生成的。该转化提供了一种收敛的方法来合成基于α-苄基-α,α-二氟酮的产物，这对于获得生物探针应该是有用的。
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