Sánchez Jiménez Araceli, Varet Julia, Poland Craig, Fern Gordon J, Hankin Steven M, van Tongeren Martie
a Centre for Human Exposure Science, Institute of Occupational Medicine (IOM) , Edinburgh , UK.
b Safenano, Institute of Occupational Medicine (IOM) , Edinburgh , UK.
J Occup Environ Hyg. 2016 Dec;13(12):936-949. doi: 10.1080/15459624.2016.1200191.
Control banding (CB) is a useful approach to evaluate and control the risk of exposure to nanomaterials (NM) due to uncertainty surrounding their toxicity and challenges associated with their measurement. Four CB tools specifically developed for NMs (NanoSafer, Stoffenmanager-Nano, NanoTool, and the Precautionary matrix) have been evaluated for their changes to differences in hazard and exposure input data. The hazard and exposure classification were also compared with experimental data. The tools provided different hazard and emission/exposure outputs when compared with each other and with experimental data. For some of the tools the information required to estimate the hazard is not always available in the Safety Data Sheet and it requires expert judgement. The tools have the potential to be valuable starting points to assess areas of high priority, although outputs should be interpreted with care. Further work should be done to improve their estimates, especially the inclusion of modifiers that account for the effectiveness of the ventilation and the effect of high temperatures during the process.
控制带法（CB）是一种有用的方法，用于评估和控制由于纳米材料（NM）毒性的不确定性及其测量相关挑战而导致的纳米材料暴露风险。已经对专门为纳米材料开发的四种控制带工具（NanoSafer、Stoffenmanager-Nano、NanoTool和预防矩阵）在危害和暴露输入数据差异方面的变化进行了评估。还将危害和暴露分类与实验数据进行了比较。与彼此以及与实验数据相比，这些工具提供了不同的危害和排放/暴露输出。对于某些工具而言，安全数据表中并不总是具备估计危害所需的信息，这需要专家判断。这些工具有可能成为评估高优先级领域的有价值的起点，不过对其输出结果的解读应谨慎。应进一步开展工作以改进其估计，特别是纳入考虑通风有效性和过程中高温影响的修正因子。
