Spiess Philippe E, Dhillon Jasreman, Baumgarten Adam S, Johnstone Peter A, Giuliano Anna R
Associate Member, Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL.
Assistant Member, Department of Anatomical Pathology, Moffitt Cancer Center, Tampa, FL.
CA Cancer J Clin. 2016 Nov 12;66(6):481-495. doi: 10.3322/caac.21354. Epub 2016 Jun 17.
Answer questions and earn CME/CNE Squamous cell carcinoma (SCC) of the penis is a rare malignancy in the United States, with a significantly higher incidence-up to 20 to 30 times greater-in areas of Africa and South America. This can be explained in part by the significantly greater prevalence of sexually transmitted diseases among high-risk males often having unprotected sex with multiple sexual partners. Human papillomavirus (HPV) has been implicated as the infectious pathway by which several these penile neoplasms originate from precursor lesions. In this regard, a fundamental understanding of HPV in penile carcinogenesis can have meaningful implications in understanding 1) the diagnosis of HPV-related precursor penile lesions, 2) targeting HPV-specific molecular pathways, and 3) cancer prevention. Using vaccination programs not only may improve patient outcomes but also may minimize the need for highly aggressive and often debilitating surgical resection. CA Cancer J Clin 2016;66:481-495. © 2016 American Cancer Society.
回答问题并获得继续医学教育/护理继续教育学时 阴茎鳞状细胞癌（SCC）在美国是一种罕见的恶性肿瘤，而在非洲和南美洲部分地区，其发病率显著更高，高达20至30倍。这部分可以通过高危男性中，有多个性伴侣且经常无保护性行为的人群中，性传播疾病的患病率显著更高来解释。人乳头瘤病毒（HPV）被认为是这些阴茎肿瘤中几种由前驱病变引发的感染途径。在这方面，对HPV在阴茎癌发生过程中的基本理解，对于理解1）HPV相关阴茎前驱病变的诊断、2）针对HPV特异性分子途径以及3）癌症预防可能具有重要意义。使用疫苗接种计划不仅可能改善患者预后，还可能减少对高度激进且往往使人虚弱的手术切除的需求。《CA：临床医师癌症杂志》2016年；66：481 - 495。© 2016美国癌症协会
