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Design and engineering of deimmunized biotherapeutics.
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Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate.
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4
Mapping the Pareto optimal design space for a functionally deimmunized biotherapeutic candidate.
PLoS Comput Biol. 2015 Jan 8;11(1):e1003988. doi: 10.1371/journal.pcbi.1003988. eCollection 2015 Jan.
5
MHCEpitopeEnergy, a Flexible Rosetta-Based Biotherapeutic Deimmunization Platform.
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Design and analysis of immune-evading enzymes for ADEPT therapy.
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Structure-based redesign of proteins for minimal T-cell epitope content.
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Engineering therapeutic antibodies for patient safety: tackling the immunogenicity problem.
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Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads.
Biotechnol Bioeng. 2015 Jul;112(7):1306-18. doi: 10.1002/bit.25554. Epub 2015 Feb 23.

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Enzyme-Based Anti-Inflammatory Therapeutics for Inflammatory Diseases.
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A Targeted Nanotoxin Inhibits Colorectal Cancer Growth Through Local Tumor Pyroptosis and Eosinophil Infiltration and Degranulation.
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Robust genome and cell engineering via in vitro and in situ circularized RNAs.
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Robust Prediction of Relative Binding Energies for Protein-Protein Complex Mutations Using Free Energy Perturbation Calculations.
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Reducing Immunogenicity by Design: Approaches to Minimize Immunogenicity of Monoclonal Antibodies.
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Accelerating therapeutic protein design with computational approaches toward the clinical stage.
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本文引用的文献

1
Computationally driven antibody engineering enables simultaneous humanization and thermostabilization.
Protein Eng Des Sel. 2016 Oct;29(10):419-426. doi: 10.1093/protein/gzw024. Epub 2016 Jun 21.
3
Mouse Models for Assessing Protein Immunogenicity: Lessons and Challenges.
J Pharm Sci. 2016 May;105(5):1567-1575. doi: 10.1016/j.xphs.2016.02.031. Epub 2016 Apr 1.
4
Immunogenicity to Biotherapeutics - The Role of Anti-drug Immune Complexes.
Front Immunol. 2016 Feb 2;7:21. doi: 10.3389/fimmu.2016.00021. eCollection 2016.
6
Immunogenicity of Therapeutic Protein Aggregates.
J Pharm Sci. 2016 Feb;105(2):417-430. doi: 10.1016/j.xphs.2015.11.002.
7
Engineering less immunogenic and antigenic FVIII proteins.
Cell Immunol. 2016 Mar;301:12-7. doi: 10.1016/j.cellimm.2015.10.008. Epub 2015 Nov 2.
8
DNA shuffling of uricase gene leads to a more "human like" chimeric uricase with increased uricolytic activity.
Int J Biol Macromol. 2016 Jan;82:522-9. doi: 10.1016/j.ijbiomac.2015.10.053. Epub 2015 Oct 23.
9
Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development.
Toxins (Basel). 2015 Oct 10;7(10):4067-82. doi: 10.3390/toxins7104067.
10
Characterisation of a Novel Anti-CD52 Antibody with Improved Efficacy and Reduced Immunogenicity.
PLoS One. 2015 Sep 15;10(9):e0138123. doi: 10.1371/journal.pone.0138123. eCollection 2015.

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