Zhang Ying, Li Xiaoping, Yu Hongtao
a Department of Chemistry and Biochemistry , Jackson State University , Jackson , Mississippi , USA.
b Center for Nano-Environmental Science and Health, Shaanxi Normal University , Xi'an , China.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2016 Jul 2;34(3):204-215. doi: 10.1080/10590501.2016.1202762.
Surface coating agents for metal nanoparticles, cationic alkyl ammonium bromides, and anionic alkyl sulfates were tested against human skin keratinocytes (HaCaT) and blood T lymphocytes (TIB-152). The surfactants of short chain (C8) are not cytotoxic, but as chain length increases, their cytotoxicity increases and levels off at C12 for cationic surfactants against both cell lines and for anionic surfactants against the TIB-152, but C14 for anionic surfactants against HaCaT. The cationic surfactants are more toxic than the anionic surfactants for HaCaT; while with similar cytotoxicity for TIB-152 cells. di- and tetra-Alkyl ammonium salts are more cytotoxic than the mono-substituted.
对金属纳米颗粒的表面涂层剂、阳离子烷基溴化铵和阴离子烷基硫酸盐进行了针对人皮肤角质形成细胞（HaCaT）和血液T淋巴细胞（TIB - 152）的测试。短链（C8）表面活性剂无细胞毒性，但随着链长增加，其细胞毒性增大，对于阳离子表面活性剂，针对两种细胞系在C12时细胞毒性趋于稳定，对于阴离子表面活性剂，针对TIB - 152细胞在C12时细胞毒性趋于稳定，而针对HaCaT细胞在C14时细胞毒性趋于稳定。对于HaCaT细胞，阳离子表面活性剂比阴离子表面活性剂毒性更大；而对于TIB - 152细胞，二者细胞毒性相似。二烷基和四烷基铵盐比单取代铵盐的细胞毒性更大。
