Suciu Maria, Ionescu Corina M, Ciorita Alexandra, Tripon Septimiu C, Nica Dragos, Al-Salami Hani, Barbu-Tudoran Lucian
Department of Molecular Biology and Biotechnology, Electron Microscopy Laboratory, Biology and Geology Faculty, Babes-Bolyai University, 5-7 Clinicilor Str., Cluj-Napoca, Cluj County, 400006, Romania.
Electron Microscopy Integrated Laboratory, National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath Str., Cluj-Napoca, Cluj County, 400293, Romania.
Beilstein J Nanotechnol. 2020 Jul 27;11:1092-1109. doi: 10.3762/bjnano.11.94. eCollection 2020.
Superparamagnetic iron oxide nanoparticles (SPIONs) have unique properties with regard to biological and medical applications. SPIONs have been used in clinical settings although their safety of use remains unclear due to the great differences in their structure and in intra- and inter-patient absorption and response. This review addresses potential applications of SPIONs in vitro (formulations), ex vivo (in biological cells and tissues) and in vivo (preclinical animal models), as well as potential biomedical applications in the context of drug targeting, disease treatment and therapeutic efficacy, and safety studies.
超顺磁性氧化铁纳米颗粒（SPIONs）在生物和医学应用方面具有独特的性质。尽管由于其结构以及患者体内和患者之间的吸收与反应存在巨大差异，其使用安全性尚不清楚，但SPIONs已在临床环境中得到应用。本综述探讨了SPIONs在体外（制剂）、离体（在生物细胞和组织中）和体内（临床前动物模型）的潜在应用，以及在药物靶向、疾病治疗、治疗效果和安全性研究方面的潜在生物医学应用。
