[甜味溶液缓解1至12个月婴儿接种疫苗所致疼痛的疗效：一项系统评价]
[Efficacy of sweet solutions in relieving pain caused by vaccination in infants aged 1 to 12 months: a systematic review].
作者信息
Chen Shao-Lin, Denise Harrison, Huang Rui-Rui, Zhang Qing, Xie Ri-Hua, Wen Shi-Wu
机构信息
School of Nursing, Hunan University of Medicine, Huaihua, Hunan 418000, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2016 Jun;18(6):534-40. doi: 10.7499/j.issn.1008-8830.2016.06.013.
OBJECTIVE
To investigate the efficacy of oral sweet solutions in relieving pain caused by vaccination in infants aged 1 to 12 months.
METHODS
Related databases were searched to find related randomized control trails (RCTs). The quality of these RCTs was evaluated. The Meta analysis was performed using RevMan 5.3.
RESULTS
A total of 20 RCTs involving 2 376 infants were included, and quality assessment showed that 6 RCTs had grade A quality and 14 had grade B quality. The Meta analysis showed that compared with sterile water, 25%-75% oral sweet solution significantly reduced crying time (WMD=-21.16, 95%CI -39.66 to -2.77, P<0.05) and the proportion of crying time (the duration of crying /3-minute periods after the injection) (WMD=-13.83, 95%CI -20.88 to -6.78, P<0.01), while the crying time showed no significant difference between the group treated with oral administration of 12% sucrose solution and non-intervention group. Co
ONCLUSIONS
Oral sweet solution (25%-75%; 2 mL) given 2 minutes before vaccination can effectively relieve the pain caused by vaccination in infants aged 1-12 months.
目的
探讨口服甜味溶液对1至12个月婴儿预防接种所致疼痛的缓解效果。
方法
检索相关数据库以查找相关随机对照试验（RCT）。对这些RCT的质量进行评估。使用RevMan 5.3进行Meta分析。
结果
共纳入20项涉及2376名婴儿的RCT，质量评估显示6项RCT为A级质量，14项为B级质量。Meta分析表明，与无菌水相比，25%-75%的口服甜味溶液显著缩短了哭闹时间（加权均数差[WMD]=-21.16，95%可信区间[CI]-39.66至-2.77，P<0.05）以及哭闹时间比例（注射后3分钟内哭闹持续时间）（WMD=-13.83，95%CI-20.88至-6.78，P<0.01），而口服12%蔗糖溶液治疗组与未干预组的哭闹时间差异无统计学意义。
结论
接种前2分钟给予口服甜味溶液（25%-75%；2mL）可有效缓解1至12个月婴儿预防接种所致的疼痛。
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