Shimizu Hirotaka, Arai Katsuhiro, Abe Jun, Nakabayashi Kazuhiko, Yoshioka Takako, Hosoi Kenji, Kuroda Makoto
Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Pediatr Int. 2016 Aug;58(8):781-5. doi: 10.1111/ped.12967. Epub 2016 Jun 21.
We report the case of an 11-year-old girl with ulcerative colitis refractory to conventional therapy, who was subsequently treated successfully with repeated fecal microbiota transplantation (FMT). The patient was steroid dependent despite several infliximab treatments, and colectomy was proposed to improve quality of life. After repeated FMT, she was able to maintain remission with on minimal dose of steroid. Although her fecal microbiota was dysbiotic before FMT, it was restored to a similar pattern as the donor after repeated FMT.
我们报告了一例11岁患有溃疡性结肠炎的女孩，其对传统治疗无效，随后通过反复粪菌移植（FMT）成功治愈。尽管接受了多次英夫利昔单抗治疗，该患者仍依赖类固醇，为改善生活质量建议进行结肠切除术。经过反复FMT后，她能够以最小剂量的类固醇维持缓解状态。虽然她在FMT前的粪便微生物群失调，但在反复FMT后恢复到与供体相似的模式。
