Maruyama T, Kimura M
Proc Natl Acad Sci U S A. 1978 Feb;75(2):919-22. doi: 10.1073/pnas.75.2.919.
Mathematical treatments are presented that enable us to compute the amount of genetic variability maintained in a finite population, assuming that mutations occur in stepwise fashion and that both selectively neutral and slightly deleterious alleles are involved. Two numerical examples show that, if very slightly deleterious mutations are prevalent, the amount of genetic variability increases much more slowly as the population number increases than is the case when all the mutations are strictly neutral.
本文提出了一些数学处理方法，这些方法能让我们计算有限群体中维持的遗传变异性的数量，假设突变以逐步的方式发生，并且涉及选择性中性和轻度有害的等位基因。两个数值例子表明，如果非常轻微的有害突变普遍存在，那么随着群体数量增加，遗传变异性的增加速度比所有突变都严格中性的情况要慢得多。
