Bermejo-Pareja F, Llamas-Velasco S, Villarejo-Galende A
Imas12 (Instituto de Investigación Hospital Universitario 12 de Octubre), Madrid, España; Cátedra Extraordinaria de Alzheimer y enfermedades Neurodegenerativas, Departamento de Medicina, Facultad de Medicina, Universidad Complutense, Madrid, España; CIBERNED, Instituto de Investigación Carlos III, Madrid, España.
Imas12 (Instituto de Investigación Hospital Universitario 12 de Octubre), Madrid, España; Departamento de Neurología, Hospital Universitario 12 de Octubre, Madrid, España.
Rev Clin Esp (Barc). 2016 Dec;216(9):495-503. doi: 10.1016/j.rce.2016.05.010. Epub 2016 Jun 17.
This review proposes a more optimistic view of Alzheimer's disease (AD), in contrast to that contributed by the ageing of the population and the failure of potentially curative therapies (vaccines and others). Treatment failure is likely due to the fact that AD gestates in the brain for decades but manifests in old age. This review updates the concept of AD and presents the results of recent studies that show that primary prevention can reduce the incidence and delay the onset of the disease. Half of all cases of AD are potentially preventable through education, the control of cardiovascular risk factors, the promotion of healthy lifestyles and specific drug treatments. These approaches could substantially reduce the future incidence rate of this disease.
与人口老龄化以及潜在治愈性疗法（疫苗及其他疗法）的失败所导致的情况相比，本综述对阿尔茨海默病（AD）提出了一种更为乐观的看法。治疗失败可能是因为AD在大脑中潜伏数十年才在老年时显现出来。本综述更新了AD的概念，并展示了近期研究的结果，这些结果表明一级预防可以降低发病率并延缓疾病的发作。通过教育、控制心血管危险因素、推广健康的生活方式以及特定的药物治疗，所有AD病例中有一半是有可能预防的。这些方法可以大幅降低该疾病未来的发病率。
