Pediatrics. 2016 Jul;138(1). doi: 10.1542/peds.2016-1493. Epub 2016 Jun 20.
Blood lead concentrations have decreased dramatically in US children over the past 4 decades, but too many children still live in housing with deteriorated lead-based paint and are at risk for lead exposure with resulting lead-associated cognitive impairment and behavioral problems. Evidence continues to accrue that commonly encountered blood lead concentrations, even those below 5 µg/dL (50 ppb), impair cognition; there is no identified threshold or safe level of lead in blood. From 2007 to 2010, approximately 2.6% of preschool children in the United States had a blood lead concentration ≥5 µg/dL (≥50 ppb), which represents about 535 000 US children 1 to 5 years of age. Evidence-based guidance is available for managing increased lead exposure in children, and reducing sources of lead in the environment, including lead in housing, soil, water, and consumer products, has been shown to be cost-beneficial. Primary prevention should be the focus of policy on childhood lead toxicity.
在过去的 40 年里,美国儿童的血液铅浓度大幅下降,但仍有太多儿童生活在含铅油漆恶化的住房中,面临铅暴露的风险,导致铅相关的认知障碍和行为问题。有越来越多的证据表明,即使血液铅浓度低于 5μg/dL(50ppb),也会损害认知;血液中的铅含量没有确定的阈值或安全水平。2007 年至 2010 年,美国约有 2.6%的学龄前儿童血液铅浓度≥5μg/dL(≥50ppb),这代表了约 53.5 万 1 至 5 岁的美国儿童。有循证指导可用于管理儿童铅暴露增加的情况,减少环境中的铅源,包括住房、土壤、水和消费产品中的铅,已被证明具有成本效益。政策应将儿童铅毒性的一级预防作为重点。