Lanphear Bruce P, Hornung Richard, Ho Mona
Cincinnati Children's Environmental Health Center, Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
Public Health Rep. 2005 May-Jun;120(3):305-10. doi: 10.1177/003335490512000315.
Screening children to identify those with blood lead levels > or = 10 microg/dl fails to protect children from lead-associated cognitive deficits and behavioral problems. To broaden our efforts at primary prevention, screening criteria are needed to identify lead-contaminated housing before children are unduly exposed. The purpose of this study was to identify and validate housing characteristics associated with children having elevated blood lead levels (> or = 10 microg/dl).
Two existing studies were used to examine housing characteristics linked with undue lead exposure: a cross-sectional study of 205 children aged 12 to 31 months, and a random sample from a longitudinal study of 276 children followed from 6 to 24 months of age. Logistic regression analysis was conducted to examine the association of children's blood lead levels > or = 10 microg/dl.
The mean age of the 481 children was 17.8 months; 99 (20.6%) had a blood lead concentration of 10 microg/dl or higher. The following characteristics were associated with blood lead concentration > or = 10 microg/dl: floor lead loading > 15 microg/ft2 (odds ratio [OR]=2.2; 95% confidence interval [CI] 1.3, 3.8); rental housing (OR=3.2; 95% CI 1.3, 7.6); poor housing condition (OR=2.1; CI 1.2, 3.6); African American race (OR=3.3; CI 1.9, 6.1); paint chip ingestion (OR=5.8; CI 1.3, 26.5); and soil ingestion (OR=2.2; CI 1.1, 4.2). Housing characteristics including rental status, lead-contaminated floor dust, and housing condition had a range of sensitivity from 47% to 92%; specificity from 28% to 76%; a positive predictive value from 25% to 34%; and a negative predictive value of 85% to 93%.
Housing characteristics and floor dust lead levels can be used to screen housing to identify lead hazards prior to occupancy, before purchasing a home, or after renovation to prevent children's exposure to lead hazards.
筛查血铅水平≥10微克/分升的儿童并不能保护儿童免受铅相关认知缺陷和行为问题的影响。为了扩大我们的一级预防工作,需要制定筛查标准,以便在儿童过度接触铅之前识别出受铅污染的住房。本研究的目的是识别并验证与血铅水平升高(≥10微克/分升)的儿童相关的住房特征。
两项现有研究用于检查与过度铅暴露相关的住房特征:一项对205名12至31个月大儿童的横断面研究,以及一项从276名6至24个月大儿童的纵向研究中随机抽取的样本。进行逻辑回归分析以检查儿童血铅水平≥10微克/分升的相关性。
481名儿童的平均年龄为17.8个月;99名(20.6%)血铅浓度为10微克/分升或更高。以下特征与血铅浓度≥10微克/分升相关:地板铅负荷>15微克/平方英尺(比值比[OR]=2.2;95%置信区间[CI]1.3, 3.8);出租房屋(OR=3.2;95% CI 1.3, 7.6);住房条件差(OR=2.1;CI 1.2, 3.6);非裔美国人种族(OR=3.3;CI 1.9, 6.1);吞食油漆碎片(OR=5.8;CI 1.3, 26.5);以及吞食土壤(OR=2.2;CI 1.1, 4.2)。包括出租状态、受铅污染的地板灰尘和住房条件在内的住房特征的敏感性范围为47%至92%;特异性范围为28%至76%;阳性预测值范围为25%至34%;阴性预测值为85%至93%。
住房特征和地板灰尘铅水平可用于在入住前、购房前或翻新后筛查住房,以识别铅危害,防止儿童接触铅危害。