Bayston R, Grove N, Siegel J, Lawellin D, Barsham S
Department of Paediatric Surgery, Institute of Child Health, London, UK.
J Neurol Neurosurg Psychiatry. 1989 May;52(5):605-9. doi: 10.1136/jnnp.52.5.605.
A process is described by which hydrocephalus shunt catheters can be impregnated with antimicrobials. The processed catheters showed antimicrobial activity at their surfaces for long periods and could be sterilised by autoclaving. When tested in vitro in a model of catheter colonisation using large challenge doses of Staphylococcus epidermidis and prolonged perfusion, some antimicrobials failed to protect against colonisation whereas others protected against one or two challenges. A combination of rifampicin and clindamycin gave best results, protecting against three successive challenges over a 28 day perfusion period. Resistant organisms did not develop. The process is likely to be useful in prevention of hydrocephalus shunt infection.
本文描述了一种使脑积水分流导管浸渍抗菌剂的方法。经过处理的导管在其表面长时间显示出抗菌活性，并且可以通过高压灭菌进行消毒。在使用大量表皮葡萄球菌攻击剂量和延长灌注时间的导管定植模型中进行体外测试时，一些抗菌剂未能防止定植，而其他抗菌剂则能抵御一到两次攻击。利福平与克林霉素的组合效果最佳，在28天的灌注期内可抵御三次连续攻击。未出现耐药菌。该方法可能有助于预防脑积水分流感染。
