解析人类 ILC 异质性：不仅仅是三个亚群。
Dissecting human ILC heterogeneity: more than just three subsets.
机构信息
Agency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN), Singapore.
出版信息
Immunology. 2018 Mar;153(3):297-303. doi: 10.1111/imm.12862. Epub 2017 Dec 26.
Abstract
Innate lymphoid cells (ILCs) have been divided into three distinct groups based on functional capacities, cytokine profiles and transcription factor expression. Studies performed mainly in mice have demonstrated the importance of ILCs in chronic inflammation, infection, allergy and cancer. In this review, we discuss the heterogeneity of human ILC and focus primarily on the taxonomy of human ILC cell subsets and their phenotypical and functional diversity. We summarize recent findings concerning the diversity of ILCs between and within the major subsets [natural killer (NK), ILC1, intra-epithelial ILC1 (ieILC1), ILC2, ILC3, lymphoid tissues inducer (LTi) and ILC progenitor (ILCP)], as well as the abundance of each in human tissues. We also discuss the similarities observed between groups of cells in term of receptors expressed and cytokines produced, and how these relate to the pleiotropic properties of each subset.
摘要
先天淋巴细胞 (ILCs) 根据功能能力、细胞因子谱和转录因子表达已被分为三个不同的组。主要在小鼠中进行的研究表明了 ILCs 在慢性炎症、感染、过敏和癌症中的重要性。在这篇综述中，我们讨论了人类 ILC 的异质性，并主要关注人类 ILC 细胞亚群的分类以及它们的表型和功能多样性。我们总结了最近关于主要亚群（自然杀伤 (NK)、ILC1、上皮内 ILC1（ieILC1）、ILC2、ILC3、淋巴组织诱导 (LTi) 和 ILC 祖细胞 (ILCP)）之间以及每个亚群内 ILCs 多样性的发现，以及每种细胞在人体组织中的丰富程度。我们还讨论了在表达的受体和产生的细胞因子方面观察到的细胞群之间的相似性，以及这些如何与每个亚群的多效性特性相关。
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